Company Name: |
Nanjing Baifuli Technology Co., Ltd.
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Tel: |
25-25-58740604 15951658055 |
Email: |
sales@unisyn.cn |
Products Intro: |
Product Name:Erythrofuranosyladenine CAS:17019-46-4 Purity:98% HPLC Package:On Request (按需包装)
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Company Name: |
TargetMol Chemicals Inc.
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Tel: |
4008200310 |
Email: |
marketing@tsbiochem.com |
Products Intro: |
Product Name:Erythrofuranosyladenine;Erythrofuranosyladenine CAS:17019-46-4 Purity:98% Package:5 mg
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| (2R,3R,4R)-2-(6-aMino-9H-purin-9-yl)tetrahydrofuran-3,4-diol Basic information |
| (2R,3R,4R)-2-(6-aMino-9H-purin-9-yl)tetrahydrofuran-3,4-diol Chemical Properties |
| (2R,3R,4R)-2-(6-aMino-9H-purin-9-yl)tetrahydrofuran-3,4-diol Usage And Synthesis |
Description | Erythrofuranosyladenine, also known as 9-beta-D-Erythrofuranosyladenine and ETA, is a nontoxic MTAP substrate. Erythrofuranosyladenine is an effective salvage agent for methylthioadenosine phosphorylase–selective therapy of T-cell acute lymphoblastic leukemia with L-alanosine. The cytotoxicity of EFA to hematopoietic progenitors erythroid burst-forming units (BFU-Es) and granulocyte-macrophage colony-forming units (CFU-GMs) was at least 26- to 41-fold less than that of MTA. EFA selectively rescued MTAP+ MOLT-4 cells from L-alanosine toxicity at 25 microM with negligible toxicity even at 100 microM. EFA is an effective agent for salvaging MTAP+ cells from L-alanosine toxicity and is superior to MTA due to lower cytotoxicity. |
| (2R,3R,4R)-2-(6-aMino-9H-purin-9-yl)tetrahydrofuran-3,4-diol Preparation Products And Raw materials |
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