2-TrifluoroMethyl-2'-Methoxychalcone 基本信息
| 中文名称 | 2-TrifluoroMethyl-2'-Methoxychalcone |
|---|---|
| 中文同义词 | 2-三氟甲基-2'-甲氧基查尔酮 |
| 英文名称 | 2-TrifluoroMethyl-2'-Methoxychalcone |
| 英文同义词 | 2-TrifluoroMethyl-2'-Methoxychalcone;2-Propen-1-one, 1-(2-methoxyphenyl)-3-[2-(trifluoromethyl)phenyl]-, (2E)-;(2E)-1-(2-Methoxyphenyl)-3-[2-(trifluoromethyl)phenyl]-2-propen-1-one;2-Trifluoromethyl-2'-methoxychalcone |
| CAS号 | 1309371-03-6 |
| 分子式 | C17H13F3O2 |
| 分子量 | 306.28 |
| EINECS号 | |
| 相关类别 | Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol文件 | 1309371-03-6.mol |
| 结构式 |  |
2-TrifluoroMethyl-2'-Methoxychalcone 性质
| 沸点 | 395.6±42.0 °C(Predicted) |
|---|---|
| 密度 | 1.238±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 乙醇中≤11mg/ml；DMSO 中≤5mg/ml；二甲基甲酰胺中≤14mg/ml |
| 形态 | 醋酸盐溶液 |
用途
2-Trifluoromethyl-2'-methoxychalcone is a novel chalcone derivative as potent Nrf2 activators in mice and human lung epithelial cells. 2-Trifluoromethyl-2'-methoxychalcone is a potent activator of Nr f2, both, in vitro and in mice. 4 Human bronchial epithelial cells treated with 10 μM 2-trifluoromethyl-2'-methoxychalcone showed a marked increase in the expression of the Nrf2-regulated antioxidant genes, GCLM and NQO1.