DMA
| 中文名称 | DMA |
|---|---|
| 中文同义词 | 2'-(3,4-二甲氧基苯基)-5-(4-甲基哌嗪-1-基)-1H,1'H-2,5'-联苯并[D]咪唑;2'-(3,4-二甲氧基苯基)-5-(4-甲基-1-哌嗪基)-2,5'-双[1H-苯并咪唑](DMA);2'-(3,4-二甲氧基苯基)-5-(4-甲基-1-哌嗪基)-2,5'-双[1H-苯并咪唑](DMA);2'-(3,4-二甲氧基苯基)-5-(4-甲基哌嗪-1-基)-1H,1'H-2,5'-联苯并[D]咪唑 |
| 英文名称 | DMA |
| 英文同义词 | 2,5'-Bi-1H-benzimidazole, 2'-(3,4-dimethoxyphenyl)-5-(4-methyl-1-piperazinyl)-;2'-(3,4-Dimethoxyphenyl)-5-(4-methylpiperazin-1-yl)-1H,1'H-2,5'-bibenzo[d]imidazole;2'-(3,4-Dimethoxyphenyl)-5-(4-methylpiperazin-1-yl)-1H,1'H-2,5'-bibenzo[d]imidazole |
| CAS号 | 188860-26-6 |
| 分子式 | C27H28N6O2 |
| 分子量 | 468.55 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 188860-26-6.mol |
| 结构式 |  |
DMA 性质
| 熔点 | 220 °C |
|---|---|
| 沸点 | 737.3±70.0 °C(Predicted) |
| 密度 | 1.292±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | DMSO：≥54mg/mL（115.25mM）； |
| 形态 | 粉末 |
| 酸度系数(pKa) | 10.78±0.10(Predicted) |
| 颜色 | 浅棕色至棕色 |
DMA 是一种荧光化合物 (λex=340 nm, λem=478 nm)。
IC50: 3.4 μM (HeLa cell), 5.3 μM (MCF7 cell)
The newly synthesized bisbenzimidazole derivatives DMA (6c) is evaluated for their cytotoxicity against human tumor cell lines, which are cervix carcinoma cell line (HeLa), breast carcinoma cell line (MCF7) and brain glioma cell line (U87) in comparison to Hoechst. In case of MCF7, the IC 50 is observed at 5.3 μM for DMA. The IC 50 determined in the case of HeLa is 3.4 μM for DMA.