抑胃酶氨酰-21
中文名称 | 抑胃酶氨酰-21 |
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中文同义词 | 抑胃酶氨酰-21;8-羟基-3-甲基-3,4-二氢苯并蒽-1,7,12(2H)-三酮;化合物STA-21 |
英文名称 | STA 21 |
英文同义词 | STA 21;Ochromycinone (STA-21);8-HYDROXY-3-METHYL-1,2,3,4,7,12-HEXAHYDROTETRAPHENE-1,7,12-TRIONE;STA-21 >=95% (HPLC);(Rac)-STA-21;8-Hydroxy-3-methyl-3,4-dihydrotetraphene-1,7,12(2H)-trione;8-Hydroxy-3-methyl-3,4-dihydrotetraphene-1,7,12(2H)-trione[STA21;anticancer,Ochromycinone,Bacterial,dimerization,binding,STAT3,Inhibitor,antimicrobial,STAT,inhibit,DNA,antibiotic |
CAS号 | 111540-00-2 |
分子式 | C19H14O4 |
分子量 | 306.31 |
EINECS号 | |
相关类别 | |
Mol文件 | 111540-00-2.mol |
结构式 | ![]() |
抑胃酶氨酰-21 性质
沸点 | 568.6±50.0 °C(Predicted) |
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密度 | 1.387±0.06 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 溶于二甲基亚砜 |
形态 | 结晶固体 |
酸度系数(pKa) | 6.61±0.40(Predicted) |
颜色 | 浅黄至黄色 |
Ochromycinone ((Rac)-STA-21)是一种天然抗生素,也是一种 STAT3 抑制剂。Ochromycinone 可抑制 STAT3 DNA结合活性,STAT3 二聚化。Ochromycinone 具有抗癌和抗菌活性。
STAT3
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STA-21 inhibits STAT3 DNA binding activity, STAT3 dimerization, and STAT3-dependent luciferase activity. Moreover, STA-21 reduces the survival of breast carcinoma cells with constitutive STAT3 signaling but has minimal effect on the cells in which constitutive STAT3 signaling is absent.