GSK3987 manufacturers
- GSK3987
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- $58.00 / 1mg
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2024-10-31
- CAS:264206-85-1
- Min. Order:
- Purity: 99.48%
- Supply Ability: 10g
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| | GSK3987 Basic information |
| Product Name: | GSK3987 | | Synonyms: | GSK3987;GSK3987 1-benzyl-3-((4-methoxyphenyl)amino)-4-phenyl-1H-pyrrole-2,5-dione;macrophages,GSK 3987,cellular cholesterol,inhibit,ABCA1,HepG2 cells,Inhibitor,SREBP-1c,LXR,Liver X receptor,triglyceride accumulation,GSK3987,GSK-3987;1H-Pyrrole-2,5-dione, 3-[(4-methoxyphenyl)amino]-4-phenyl-1-(phenylmethyl)-;LXRα/β Agonist;1-Benzyl-3-((4-methoxyphenyl)amino)-4-phenyl-1H-pyrrole-2,5-dione | | CAS: | 264206-85-1 | | MF: | C24H20N2O3 | | MW: | 384.43 | | EINECS: | | | Product Categories: | | | Mol File: | 264206-85-1.mol |  |
| | GSK3987 Chemical Properties |
| Boiling point | 572.4±50.0 °C(Predicted) | | density | 1.309±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMSO: 200 mg/ml,Methanol: 100 mg/ml | | form | A solid | | pka | -1.27±0.20(Predicted) | | color | Light yellow to yellow |
| | GSK3987 Usage And Synthesis |
| Biological Activity | GSK3987 is a dual agonist of liver X receptor α (LXRα) and LXRβ.1 It recruits steroid receptor coactivator 1 (SRC-1) to LXRα and LXRβ in a ligand-sensing assay (LiSA; EC50s = 50 and 40 nM, respectively). GSK3987 is 50-fold selective for LXRα and LXRβ over a panel of nuclear receptors and GSK3β (IC50 = >5,000 nM) but does induce ABCA1 expression in a reporter assay using THP-1 cells (EC50 = 80 nM). It inhibits LPS-induced IL-6 secretion in THP-1 macrophages. GSK3987 increases the expression of the sterol regulatory element binding protein 1c (SREBP-1c) and induces triglyceride accumulation in HepG2 cells in a concentration-dependent manner. | | References | 1.Jaye, M.C., Krawiec, J.A., Campobasso, N., et al.Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structureJ. Med. Chem.48(17)5419-5422(2005) |
| | GSK3987 Preparation Products And Raw materials |
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