|
|
| Product Name: | OTS964 | | Synonyms: | OTS964;(R)-9-[4-[1-(Dimethylamino)propan-2-yl]phenyl]-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-one Hydrochloride;(R)-9-(4-(1-(dimethylamino)propan-2-yl)phenyl)-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-one;OTS964 HYDROCHLORIDE;OTS964; OTS 964;CS-2531;OTS964 HCl;OTS964+OTS964 HCl | | CAS: | 1338545-07-5 | | MF: | C23H24N2O2S | | MW: | 392.51386 | | EINECS: | | | Product Categories: | API | | Mol File: | 1338545-07-5.mol |  |
| | OTS964 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | ≥88.6 mg/mL in DMSO; ≥2.15 mg/mL in EtOH with gentle warming and ultrasonic; ≥2.1 mg/mL in H2O with gentle warming and ultrasonic | | form | crystalline solid | | color | Off-white to light yellow |
| | OTS964 Usage And Synthesis |
| Description | OTS964 is an inhibitor of lymphokine-activated killer T cell-originated protein kinase (TOPK; IC50 = 28 nM). It specifically blocks cytokinesis, leading to apoptosis, in a broad range of cancer cells. OTS964 induces apoptosis of human lung cancer cells in mouse xenografts. | | Uses | OTS 964 works through cytokinesis and is an effective TOPK inhibitor which has been shown to cause tumor suppression in xenografts of human cancer. | | references | 1. matsuo y, park jh2, miyamoto t, et al. topk inhibitor induces complete tumor regression in xenograft models of human cancer through inhibition of cytokinesis. ci transl med. 2014 oct 22;6(259):259ra145. |
| | OTS964 Preparation Products And Raw materials |
|