SB-399885 HCL
| 中文名称 | SB-399885 HCL |
|---|---|
| 中文同义词 | 化合物 T12843;SB 399885 盐酸盐 |
| 英文名称 | N-(3,5-Dichloro-2-methoxyphenyl)-4-methoxy-3-(1-piperazinyl)-benzenesulfonamide hydrochloride |
| 英文同义词 | SB399885 hydrochloride,SB 399885 hydrochloride;N-(3,5-dichloro-2-methoxyphenyl)-4-methoxy-3-(1-piperazinyl)-benzenesulfonamide, monohydrochloride |
| CAS号 | 402713-81-9 |
| 分子式 | C18H22Cl3N3O4S |
| 分子量 | 482.8 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 402713-81-9.mol |
| 结构式 |  |
SB-399885 HCL 性质
| 储存条件 | room temp |
|---|---|
| 溶解度 | H2O：可溶15mg/mL，澄清 |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
|
5-HT 6 Receptor
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Compare with the control vehicle SB-399885 hydrochloride 10 mg/kg significantly increases wakefulness (W) (F (3,15) =3.32, P<0.05) while slow wave sleep (SWS), rapid-eye-movement sleep (REMS) and the number of REM periods are reduced (F (3,15) =4.0, P<0.01; F (3,15) =3.14, P<0.05 and F (3,15) =2.62, P<0.05, respectively). Analysis of sleep variables in 2-h blocks shows that SB-399885 hydrochloride 10 mg/kg increases W (F (3,15) =5.48, P<0.01) and reduces SWS (F (3,15) =5.42, P<0.01) and REMS (F (3,15) = 4.05, P<0.01) during the first 2-h period. SB-399885 hydrochloride 5 and 10 mg/kg augment light sleep over the first (F (3,15) =3.46,P<0.01 and F (3,15) = 3.65, P<0.01, respectively) and the second (F (3,15) =3.23, P<0.05 and F (3,15) =3.08, P<0.05, respectively) 2-h recording periods. SB-399885 hydrochloride 10 mg/kg significantly increases REMS latency (F (3,15) =3.60, P<0.01) and reduces the number of REM periods during the first 2-h of recording (F (3,15) =3.88, P<0.01).