| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
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orderCN@merckgroup.com |
| Products Intro: |
Product Name:TAPI-2 acetate salt
CAS:689284-12-6
Purity:>=98% (HPLC) Package:1MG Remarks:SML0420-1MG
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| Company Name: |
BOC Sciences
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| Tel: |
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| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide
CAS:689284-12-6
Purity:≥95% by HPLC Remarks:TAPI 2 is an ADAM-17 (TACE) and matrix metalloprotease (MMP) inhibitor (Ki = 120 nM at ADAM-17). TAPI 2 sensitizes cancer stem cells to the lethal effects of 5-FU in vitro, and inhibits shedding of TN
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| | Tumor necrosis factor-α protease inhibitor-2, TNF-α protease inhibitor-2 Basic information |
| Product Name: | Tumor necrosis factor-α protease inhibitor-2, TNF-α protease inhibitor-2 | | Synonyms: | N-(R)-(2-(Hydroxyaminocarbonyl)methyl)-4-methylpentanoyl-L-t-butyl-glycine-L-alanine 2-aminoethyl amide;TAPI-2 acetate salt;Tumor necrosis factor-α protease inhibitor-2, TNF-α protease inhibitor-2;N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide;L-Alaninamide, N-[(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)- | | CAS: | 689284-12-6 | | MF: | C19H37N5O5 | | MW: | 415.53 | | EINECS: | | | Product Categories: | | | Mol File: | 689284-12-6.mol |  |
| | Tumor necrosis factor-α protease inhibitor-2, TNF-α protease inhibitor-2 Chemical Properties |
| storage temp. | -20°C | | form | lyophilized solid | | color | white to off-white |
| | Tumor necrosis factor-α protease inhibitor-2, TNF-α protease inhibitor-2 Usage And Synthesis |
| Uses | TAPI 2 is a matrix metalloprotease (MMP) inhibitor, which inhibits merpin α and β homo-oligomers. | | Biochem/physiol Actions | TAPI-2 is a potent inhibitor matrix metalloproteinases and TACE (TNF-α convertase/ADAM17/α-secretase). It blocks the shedding of several cell surface proteins such as β-amyloid precursor protein, inhibits TNF-α release as well as a diverse variety of membrane-anchored cytokines, cell adhesion molecules, receptors, ligands. TAPI-2 is considered a fairly broad metalloproteinase inhibitor, but it much more selective for TACE than GM6001. | | storage | Store at -20°C |
| | Tumor necrosis factor-α protease inhibitor-2, TNF-α protease inhibitor-2 Preparation Products And Raw materials |
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