AM12
| 中文名称 | AM12 |
|---|---|
| 中文同义词 | 化合物 T13546;化合物 AM12 |
| 英文名称 | AM12 |
| 英文同义词 | AM-12;AM12,AM-12;4H-1-Benzopyran-4-one, 2-(2-bromophenyl)-3,5,7-trihydroxy- |
| CAS号 | 2387510-84-9 |
| 分子式 | C15H9BrO5 |
| 分子量 | 349.13 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 2387510-84-9.mol |
| 结构式 |  |
AM12 性质
| 沸点 | 562.7±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.864±0.06 g/cm3(Predicted) |
| 溶解度 | 在 DMSO 中溶解度为 100 mM，在乙醇中溶解度为 50 mM |
| 酸度系数(pKa) | 6.28±0.40(Predicted) |
AM12 抑制镧系元素诱发的 TRPC5 活性，IC50 为 0.28 μM。
IC50: 0.28 μM (TRPC5)
AM12 also inhibits TRPC5 activity evoked by the agonist (-)-Englerin A.
AM12 also inhibits TRPC4 channels similarly. AM12 inhibits TRPC5 and TRPC4 channels via a site accessible from the extracellular face of the membrane, acting directly on either the channel or a site closely associated with it.
AM12 also inhibits Ca
2+
entry evoked by Gd
3+
. AM12 inhibits the Gd
3+
-evoked Ca
2+
signal with an IC
50
of 0.28 μM. AM12 is slightly more potent than the natural product Galangin as an inhibitor of the Gd
3+
-evoked signal.