| Company Name: |
TCI (Shanghai) Development Co., Ltd.
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| Tel: |
021-67121386 |
| Email: |
Sales-CN@TCIchemicals.com |
| Products Intro: |
Product Name:N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide
CAS:383418-30-2
Purity:98.0% LC Package:5MG
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| | N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide Basic information |
| | N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide Chemical Properties |
| solubility | Chloroform: soluble; DMSO: soluble | | form | powder to crystal | | color | White to Almost white | | CAS DataBase Reference | 383418-30-2 |
| | N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide Usage And Synthesis |
| Description | HPA-12 is a ceramide analog and inhibitor of ceramide transfer protein (CERT). It inhibits binding of a ceramide probe to the isolated steroidogenic acute regulatory protein-related lipid transfer (START) domain of CERT with an EC50 value of 4 μM in a TR-FRET assay. HPA-12 (2.5 μM) inhibits conversion of the fluorescent ceramide analog C5-DMB-Cer to C5-DMB-sphingomyelin in CHO and HeLa cells. It also inhibits sphingomyelin synthesis in wild-type, but not ATP-dependent ceramide transport-deficient, CHO cells when used at a concentration of 1 μM. |
| | N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide Preparation Products And Raw materials |
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