| Company Name: |
ShangHai Caerulum Pharma Discovery Co., Ltd.
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| Tel: |
18149758185 |
| Email: |
sales-cpd@caerulumpharma.com |
| Products Intro: |
Product Name:PTP Inhibitor III (4-(Bromoacetyl)phenoxyacetic Acid)
CAS:29936-81-0
Purity:98% Package:1g;10g;100g
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| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
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| Tel: |
400-9205774 |
| Email: |
sales@glpbio.cn |
| Products Intro: |
Product Name:PTP Inhibitor III
CAS:29936-81-0
Purity:>98% Package:1mg;10mg;50mg;100mg;
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:PTP Inhibitor III
CAS:29936-81-0
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
| Company Name: |
MedBioPharmaceutical Technology Inc
|
| Tel: |
021-69568360 18916172912 |
| Email: |
order@med-bio.cn |
| Products Intro: |
Product Name:PTP Inhibitor III
CAS:29936-81-0
Purity:98% Package:1mg; 5mg; 10mg Remarks:Medbio
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| | PTP Inhibitor III Basic information |
| Product Name: | PTP Inhibitor III | | Synonyms: | PTP Inhibitor III;PTP Inhibitor III - CAS 29936-81-0 - Calbiochem;4-(bromoacetyl)phenoxyacetic acid;PTP Inhibitor III (4-(Bromoacetyl)phenoxyacetic Acid);Acetic acid, 2-[4-(2-bromoacetyl)phenoxy]-;2-[4-(2-bromoacetyl)phenoxy]-aceticacid | | CAS: | 29936-81-0 | | MF: | C10H9BrO4 | | MW: | 273.08 | | EINECS: | | | Product Categories: | | | Mol File: | 29936-81-0.mol |  |
| | PTP Inhibitor III Chemical Properties |
| storage temp. | = -70C | | solubility | Soluble in DMSO (25 mg/ml) | | form | White solid | | color | White | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week. |
| | PTP Inhibitor III Usage And Synthesis |
| Description | PTP inhibitor III (29936-81-0) inhibits a broad range of protein tyrosine phosphatases (PTPs). Binds covalently to the active site of the enzyme.1-2? Blocks SHP1-mediated dephosphorylation of TRPV1 in dorsal root ganglion neurons aggravating CFA-induced inflammatory pain.3 | | Uses | PTP Inhibitor III is an α-haloacetophenone derivative that acts as a photoreversible covalent inhibitor of protein tyrosine phosphatases (PTPs). It binds the catalytic domain of SHP-1 (Ki = 184 μM) and covalently reacts with free thiols, a reaction that is reversible with irradiation (350 nm). PTP Inhibitor III is cell permeable and inhibits a broad range of PTPs.[Cayman Chemical] | | References | Kanda et al. (2006), Glutaredoxin modulates platelet-derived growth factor-dependent cell signaling by regulating the redox status of low molecular weight protein-tyrosine phosphatase; J. Biol. Chem., 281 28518
Popov et al. (2009), Vascular PTPs: current developments and challenges for exploitation in Type 2 diabetes-associated vascular dysfunction; Biochem. Biophys. Res. Commun., 389 1
Xiao et al. (2015), Shp-1 dephosphorylates TRPV1 in dorsal root ganglion neurons and alleviates CFA-induced inflammatory pain in rats; Pain, 156 597 |
| | PTP Inhibitor III Preparation Products And Raw materials |
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