Tracazolate hydrochloride
中文名称 | Tracazolate hydrochloride |
---|---|
中文同义词 | 盐酸西卡唑酯;化合物 T23470 |
英文名称 | Tracazolate hydrochloride |
英文同义词 | TUIXDPUEMQXVHO-UHFFFAOYSA-N |
CAS号 | 1135210-68-2 |
分子式 | C16H25ClN4O2 |
分子量 | 340.85 |
EINECS号 | |
相关类别 | |
Mol文件 | 1135210-68-2.mol |
结构式 |
Tracazolate hydrochloride 性质
储存条件 | Desiccate at RT |
---|---|
溶解度 | 1eq.<34.09mg/ml盐酸 |
形态 | 固体 |
颜色 | 米白色至浅黄色 |
GABA A
Tracazolate (ICI 136753) hydrochloride inhibits α1β1ε (EC
50
=4.0 μM) and α1β3ε (EC
50
=1.2 μM), α1β3 (EC
50
=2.7 μM) and α6β3γ (EC
50
=1.1 μM). Replacement of Ser265 within the β1 subunit with Asn (the β3 counterpart) increases the sensitivity of tracazolate, whereas the opposite mutation (Asnβ3 to Ser) decreases the sensitivity to Tracazolate. Tracazolate hydrochloride interacts with γ-aminobutyric acid GABA
A
receptors, adenosinereceptors, and phosphodiesterases.
Tracazolate hydrochloride (10 μM) increases the maximum current amplitude and enhances the sensitivity of α1β2δ-containing GABA
A
receptors in oocytes.