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BOC Sciences
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info@bocsci.com |
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Product Name:GB 83
CAS:1252806-86-2
Purity:99% Remarks:GB 83 is a selective antagonist of human protease activated receptor 2 (PAR2) (IC50 = 2 mM).
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GB 83 manufacturers
- GB83
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- $1980.00 / 50mg
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2024-10-28
- CAS:1252806-86-2
- Min. Order:
- Purity:
- Supply Ability: 10g
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| Product Name: | GB 83 | | Synonyms: | GB 83;GB-83
(GB83);5-Isoxazolecarboxamide, N-[(1S)-1-(cyclohexylmethyl)-2-[[(1S,2S)-1-[(2,3-dihydrospiro[1H-indene-1,4'-piperidin]-1'-yl)carbonyl]-2-methylbutyl]amino]-2-oxoethyl]-;N-[(2S)-3-cyclohexyl-1-[[(2S)-3-methyl-1-oxo-1-(1'-spiro[1,2-dihydroindene-3,4'-piperidine]yl)pentan-2-yl]amino]-1-oxopropan-2-yl]-5-isoxazolecarboxamide | | CAS: | 1252806-86-2 | | MF: | C32H44N4O4 | | MW: | 548.72 | | EINECS: | | | Product Categories: | | | Mol File: | 1252806-86-2.mol |  |
| | GB 83 Chemical Properties |
| Boiling point | 807.6±65.0 °C(Predicted) | | density | 1.20±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: 2mg/mL, clear | | pka | 12.12±0.46(Predicted) | | form | powder | | color | white to beige |
| | GB 83 Usage And Synthesis |
| Biological Activity | GB83 is a serum stable, potent and selective antagonist of human protease activated receptor 2 (PAR2)(IC50 = 2 μM) th at reversibly inhibit PAR2 activation by both proteases and PAR2 agonists. GB83 prevented upregulation of PARs, ICAM-1, LOX-1, IL-8, and activation of MAP kinases by coagulation factor X (FXa) in atrial tissue slices |
| | GB 83 Preparation Products And Raw materials |
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