287194-41-6
中文名称 | 287194-41-6 |
---|---|
中文同义词 | 2-羟基-N-[(1R,2R,6R)-2-羟基-5-氧代-7-氧杂双环[4.1.0]庚-3-烯-3-基]苯甲酰胺;(+)-DHMEQ;化合物 T13462 |
英文名称 | (+)-DHMEQ |
英文同义词 | (1R,2R,6R)-Dehydroxymethylepoxyquinomicin;(1R,2R,6R)-DHMEQ;2-hydroxy-N-[(1R,2R,6R)-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]benzamide;Benzamide, 2-hydroxy-N-[(1R,2R,6R)-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-;6R)-Dehydroxymethylepoxyquinomicin;6R)-DHMEQ;(+) DHMEQ,(+)DHMEQ |
CAS号 | 287194-41-6 |
分子式 | C13H11NO5 |
分子量 | 261.23 |
EINECS号 | |
相关类别 | |
Mol文件 | 287194-41-6.mol |
结构式 | ![]() |
287194-41-6 性质
熔点 | 184 °C |
---|---|
沸点 | 617.2±55.0 °C(Predicted) |
密度 | 1.58±0.1 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 二甲基亚砜:≥35mg/mL(133.98mM) |
酸度系数(pKa) | 8.43±0.30(Predicted) |
形态 | 固体 |
颜色 | 白色至米白色 |
Nrf2
(+)-DHMEQ ((2R,3R,4R)-DHMEQ) activates Nrf2, which is a transcription factor that induces the expression of multiple antioxidant enzymes. (+)-DHMEQ activates Nrf2 in a promoter reporter assay. (+)-DHMEQ also increases the expression of target antioxidant proteins and cancelled reactive oxygen species (ROS)-induced cell death in a neuronal cell line. ROS generating 6-hydroxydopamine hydrochloride (6-OHDA) induces the death of SK-N-SH cells, and (+)-DHMEQ decreases the cytotoxic effect of 6-OHDA, whereas its effect is weaker in Nrf2-knockdown cells prepared with siRNA. Thus, enhancement of the neural cell viability by (+)-DHMEQ is due to the activation of Nrf2.