YKL-05-099 manufacturers
- YKL-05-099
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- $68.00 / 1mg
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2024-11-18
- CAS:1936529-65-5
- Min. Order:
- Purity: 99.66%
- Supply Ability: 10g
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| | YKL-05-099 Basic information |
| Product Name: | YKL-05-099 | | Synonyms: | YKL-05-099;Pyrimido[4,5-d]pyrimidin-2(1H)-one, 3-(2-chloro-6-methylphenyl)-3,4-dihydro-7-[[2-methoxy-4-(1-methyl-4-piperidinyl)phenyl]amino]-1-(5-methoxy-2-pyridinyl)-;3-(2-Chloro-6-methylphenyl)-7-((2-methoxy-4-(1-methylpiperidin-4-yl)phenyl)amino)-1-(5-methoxypyridin-2-yl)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one;YKL05099,YKL 05 099,inhibit,Salt-inducible Kinase (SIK),Inhibitor;YKL-05-099, 10 mM in DMSO | | CAS: | 1936529-65-5 | | MF: | C32H34ClN7O3 | | MW: | 600.11 | | EINECS: | | | Product Categories: | | | Mol File: | 1936529-65-5.mol |  |
| | YKL-05-099 Chemical Properties |
| Boiling point | 761.0±70.0 °C(Predicted) | | density | 1.311±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO:103.33(Max Conc. mg/mL);172.18(Max Conc. mM) | | form | A solid | | pka | 8.63±0.20(Predicted) | | color | White to light yellow |
| | YKL-05-099 Usage And Synthesis |
| Biological Activity | Potent and selective salt-inducible kinases (SIK1, SIK2, SIK3) inhibitor in vitro and in vivo.
YKL-05-099 is a potent and selective salt-inducible kinases inhibitor (SIK1/2/3 IC50 = 10/40/30 nM) with superior pharmacokinetic properties than HG-9-91-01. YKL-05-099 pre-treatment of murine BDMCs up-regulates Zymosan A-stimulated IL-10 (EC50 = 460 nM with 24h ), while suppresses inflammatory cytokines production (TNFα, IL-6 and IL-12p40). Likewise, YKL-05-099 intraperitoneal administration in mice (20 mg/kg i.p.) 15 min prior to LPS (0.5 mg/kg i.p.) enhances serum IL-10, while reduces HDAC5 pSer259 levels in total splenic leukocytes and serum TNFα level in vivo. |
| | YKL-05-099 Preparation Products And Raw materials |
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