| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
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400-9205774 |
| Email: |
sales@glpbio.cn |
| Products Intro: |
Product Name:(2S)-OMPT
CAS:1217471-69-6
Purity:>98% Package:1mg;10mg;50mg;100mg;
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:(2S)-OMPT
CAS:1217471-69-6
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
| Company Name: |
MedBioPharmaceutical Technology Inc
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| Tel: |
021-69568360 18916172912 |
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order@med-bio.cn |
| Products Intro: |
Product Name:(2S)-OMPT
CAS:1217471-69-6
Purity:98% Package:500ug (solution); 10mg (solution); 1mg (solution); 5mg (solution) Remarks:Medbio
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| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:(2S)-OMPT
CAS:1217471-69-6
Purity:98% Package:500μg;1mg;5mg
|
| Company Name: |
Cayman Chemical Company
|
| Tel: |
(800) 364-9897 |
| Email: |
cayman@caymanchem.com |
| Products Intro: |
Product Name:(2S)-OMPT
CAS:1217471-69-6
|
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| | (2S)-OMPT Basic information |
| | (2S)-OMPT Chemical Properties |
| solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml |
| | (2S)-OMPT Usage And Synthesis |
| Description | Lysophosphatidic acid (LPA) is a potent lipid mediator that elicits its effect through four distinct receptors - LPA1/EDG-2, LPA2/EDG-4, LPA3/EDG-7 and LPA4/GPR23.1,2 OMPT is a selective agonist of the lysophosphatidic acid 3 (LPA3) receptor. It exhibits EC50 values of 68 nM and >6.8 μM for calcium mobilization in LPA1 and LPA2-expressing Sf9 cells, respectively.3 The (2S)-OMPT enantiomer is 5- to 20-fold more active than (2R)-OMPT in calcium release assays in both LPA3-transfected Sf9 and rat hepatoma Rh7777 cells.4 | | References | 1. Chun, J., Goetzl, E.J., Hla, T., et al. International union of pharmacology. XXXIV. Lysophospholipid receptor nomenclature Pharmacol. Rev. 54,265-269(2002).
2. Niu, S.L., Mitchell, D.C., and Litman, B.J. Trans fatty acid derived phospholipids show increased membrane cholesterol and reduced receptor activation as compared to their cis analogs Biochemistry 44,4458-4465(2005).
3. Hasegawa, Y., Erickson, J.R., Goddard, G.J., et al. Identification of a phosphothionate analogue of lysophosphatidic acid (LPA) as a selective agonist of the LPA3 receptor J. Biol. Chem. 278(14),11962-11969(2003).
4. Qian, L., Xu, Y., Hasegawa, Y., et al. Enantioselective responses to a phosphorothioate analogue of lysophosphatidic acid with LPA3 receptor-selective agonist activity J. Med. Chem. 46,5575-5578(2003). |
| | (2S)-OMPT Preparation Products And Raw materials |
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