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BOC Sciences
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Product Name:CAY10535
CAS:945716-28-9
Purity:98% Package:1G;10G;100G Remarks:TPα and TPβ are two isoforms of the human TP receptor, which is the G protein-coupled receptor (GPCR) that mediates the actions of thromboxane A2 (TXA2). CAY10535 is a TP receptor antagonist that sho
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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Product Name:CAY10535
CAS:945716-28-9
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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TargetMol Chemicals Inc.
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Product Name:CAY10535;CAY10535,CAY-10535
CAS:945716-28-9
Purity:98% Package:50 mg
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Shanghai Yifei Biotechnology Co. , Ltd.
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Product Name:CAY10535 Exclusive
CAS:945716-28-9
Purity:98% Package:1mg;5mg;10mg
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| | CAY10535 Exclusive Basic information |
| Product Name: | CAY10535 Exclusive | | Synonyms: | CAY10535 Exclusive;1-tert-butyl-3-[2-(3-methoxyphenoxy)-5-nitrophenyl]sulfonylurea;Benzenesulfonamide, N-[[(1,1-dimethylethyl)amino]carbonyl]-2-(3-methoxyphenoxy)-5-nitro-;CAY10535,CAY-10535 | | CAS: | 945716-28-9 | | MF: | C18H21N3O7S | | MW: | 423.44 | | EINECS: | | | Product Categories: | | | Mol File: | 945716-28-9.mol |  |
| | CAY10535 Exclusive Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 20 mg/ml; DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml; DMSO: 20 mg/ml; Ethanol: 10 mg/ml | | form | A crystalline solid |
| | CAY10535 Exclusive Usage And Synthesis |
| Description | TPα and TPβ are two isoforms of the human TP receptor, the G protein-coupled receptor (GPCR) that mediates the actions of thromboxane A2 (TXA2). Although their distinct physiological functions have not been fully elucidated, TPβ is believed to be responsible for vascular endothelial growth factor-induced endothelial cell differentiation and migration whereas TPα appears to be the predominant isoform expressed in platelets. CAY10535 is a TP receptor antagonist that shows ~20-fold selectivity for TPβ (IC50 = 99 nM) relative to TPα (IC50 = 1,970 nM) in the inhibition of U46619-mediated Ca2+ mobilization. This compound exhibits relatively poor activity on platelets (IC50 = 985 nM) when inhibiting U-46619-induced platelet aggregation.1 | | References | 1. Hanson, J., Dogné, J.M., Ghiotto, J., et al. Design, synthesis, and SAR study of a series of N-alkyl-N'-[2-(aryloxy)-5-nitrobenzenesulfonyl]ureas and -cyanoguanidine as selective antagonists of the TPα and TPβ isoforms of the human thromboxane A2 receptor J. Med. Chem. 50(16),3928-3936(2007). |
| | CAY10535 Exclusive Preparation Products And Raw materials |
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