MELFLUFEN HYDROCHLORIDE
| 中文名称 | MELFLUFEN HYDROCHLORIDE |
|---|---|
| 中文同义词 | |
| 英文名称 | Nelotanserin |
| 英文同义词 | ethyl (2S)-2-[[(2S)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoyl]amino]-3-(4-fluorophenyl)propanoate;Melflufen hydrochloride |
| CAS号 | 380449-54-7 |
| 分子式 | C24H31Cl3FN3O3 |
| 分子量 | 534.88 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 380449-54-7.mol |
| 结构式 |  |
MELFLUFEN HYDROCHLORIDE 性质
| 形态 | 固体 |
|---|---|
| 颜色 | 米白色至浅黄色 |
Melflufen (Melphalan flufenamide) hydrochloride，Melphalan 的一种二肽前体药物，是一种烷基化剂。Melflufen hydrochloride 对多发性骨髓瘤细胞具有抗肿瘤活性，并抑制血管生成。Melflufen hydrochloride 对骨髓瘤细胞 DNA 不可逆损伤及细胞毒作用。
Melflufen (Melphalan flufenamide) hydrochloride (0.5-10 μM; 24 hours) decreases viability of MM.1S, INA-6, RPMI-8226, MM.1R, Dox-40, ARP-1, and ANBL-6 cells in a concentration-dependent manner.
Melflufen hydrochloride induces apoptosis in MM.1S cells.
Melflufen hydrochloride also is a potent activator of exosome secretion.
Cell Viability Assay
| Cell Line: | Multiple myeloma cells: MM.1S, INA-6, RPMI-8226, MM.1R, Dox-40, ARP-1, ANBL-6 cells |
| Concentration: | 0.5, 1, 3, 5, 10 μM |
| Incubation Time: | 24 hours |
| Result: | A significant concentration-dependent decrease in viability of all cell lines was observed. |
Melflufen (Melphalan flufenamide) hydrochloride (3 mg/kg; i.v.; twice-weekly for two weeks) shows anti-MM activity in xenograft mouse model.
| Animal Model: | CB-17 SCID mice (human plasmacytoma MM.1S xenograft mouse model) |
| Dosage: | 3 mg/kg |
| Administration: | 1.v.; twice-weekly for two weeks |
| Result: | Significantly inhibited MM tumor growth and prolonged survival of mice. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-105019A | Melflufen hydrochloride | 1 mg | 1909元 | |
| 2024/04/30 | HY-105019A | MELFLUFEN HYDROCHLORIDE Melflufen hydrochloride | 380449-54-7 | 5mg | 4200元 |