| Company Name: |
Amatek Scientific Co. Ltd.
|
| Tel: |
0512-56316828 |
| Email: |
info@amateksci.com |
| Products Intro: |
Product Name:HO-PEG8-CH2COOH
CAS:780006-30-6
Purity:97% HPLC Package:1g;5g;25g;100g
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| Company Name: |
Guangzhou Hongyuan Chemical Co.,Ltd
|
| Tel: |
15817493340 |
| Email: |
981810490@qq.com |
| Products Intro: |
Product Name:Hydroxy-PEG8-acetic acid
CAS:780006-30-6
Purity:97% Package:1g;100g;1kg
|
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| | HO-PEG8-CH2COOH Basic information |
| Product Name: | HO-PEG8-CH2COOH | | Synonyms: | HO-PEG8-CH2COOH;HO-PEG8-CH2COOH/Acetic acid, 2-[(23-hydroxy-3,6,9,12,15,18,21-heptaoxatricos-1-yl)oxy]-;Acetic acid, 2-[(23-hydroxy-3,6,9,12,15,18,21-heptaoxatricos-1-yl)oxy]-;Hydroxy-PEG8-acetic acid | | CAS: | 780006-30-6 | | MF: | C18H36O11 | | MW: | 428.47 | | EINECS: | | | Product Categories: | | | Mol File: | 780006-30-6.mol |  |
| | HO-PEG8-CH2COOH Chemical Properties |
| Boiling point | 543.7±45.0 °C(Predicted) | | density | 1.162±0.06 g/cm3(Predicted) | | pka | 3.39±0.10(Predicted) |
| | HO-PEG8-CH2COOH Usage And Synthesis |
| Biological Activity | HO-PEG8-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | | References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
| | HO-PEG8-CH2COOH Preparation Products And Raw materials |
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