| Company Name: |
Shanghai JiYi Biotechnology Co. Ltd.
|
| Tel: |
13621943973 |
| Email: |
sales@shjiyipharmatech.com |
| Products Intro: |
Product Name:CGP4540
CAS:100990-46-3
Purity:>98% Package:1g,5g,10g,100g,500g
|
| Company Name: |
Shanghai Chaolan Chemical Technology Center
|
| Tel: |
QQ:65489617 15618227136 |
| Email: |
info@SuperLan-chem.com |
| Products Intro: |
Product Name:CGP4540
CAS:100990-46-3
Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G,100G
|
|
| | CGP4540 Basic information |
| Product Name: | CGP4540 | | Synonyms: | CGP-4540;CGP 4540;CGP4540;NITHIOCYAMINE;CGP4540 (Amoscanate);(4-Isothiocyanato-phenyl)-(4-nitro-phenyl)-amine | | CAS: | 100990-46-3 | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![CGP4540 Structure]() |
| | CGP4540 Chemical Properties |
| | CGP4540 Usage And Synthesis |
| Definition | ChEBI: Amoscanate is an isothiocyanate that is phenyl isothiocyanate in which the hydrogen at the para- position has been replaced by a 4-nitroanilinyl group. It has a role as a schistosomicide drug. It is a C-nitro compound, an isothiocyanate and a secondary amino compound. It is functionally related to a diphenylamine. | | Biological Activity | Amoscanate (cgp4540) is phenyl isothiocyanate in which the hydrogen at the para-position has been replaced by a 4-nitroanilinyl group. Amoscanate is an anti-schistosomal agent. Amoscanate, as an isothiocyanate compound and uncoupler of oxidative phosphorylation, potently injures rodent ependyma[1].
Amoscanate (500 mg/kg; p.o.; 10 days) destructs ependyma and periventricular brain[1].Amoscanate (250 and 500 mg/kg; p.o.; 28 days) elicits necrosis, Ca++-positive microgranules, pyknosis and edema localized in ependyma/subependyma in the medial striatum[1].Amoscanate (25~500 mg/kg; p.o.; 20 days) elicits progressive necrosis of ependyma[1].Amoscanate elicits massive ultrastructural damage in ependymal cells[1]. | | References | [1]. Johanson C, et al. The distributional nexus of choroid plexus to cerebrospinal fluid, ependyma and brain: toxicologic/pathologic phenomena, periventricular destabilization, and lesion spread. Toxicol Pathol. 2011;39(1):186-212. |
| | CGP4540 Preparation Products And Raw materials |
|