| Company Name: |
TaiChem Taizhou Limited
|
| Tel: |
052386810091 |
| Email: |
zcwy9518@yeah.net |
| Products Intro: |
Product Name:3-phenyl-2-sulfanylpropanoicacid
CAS:90536-15-5
Purity:95% Package:1G;2G;5G
|
| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:PD 145305
CAS:90536-15-5
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
| Company Name: |
MedBioPharmaceutical Technology Inc
|
| Tel: |
021-69568360 18916172912 |
| Email: |
order@med-bio.cn |
| Products Intro: |
Product Name:PD 145305
CAS:90536-15-5
Purity:98% Package:10mg (solution); 5mg (solution) Remarks:Medbio
|
| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:PD 145305
CAS:90536-15-5
Purity:95% Package:1mg;5mg;10mg
|
|
| | PD 145305 Basic information |
| Product Name: | PD 145305 | | Synonyms: | PD 145305;3-phenyl-2-sulfanylpropanoic acid;S(+)-2-mercapto-3-phenylpropionic acid;Benzenepropanoic acid, α-mercapto- | | CAS: | 90536-15-5 | | MF: | C9H10O2S | | MW: | 182.24 | | EINECS: | | | Product Categories: | | | Mol File: | 90536-15-5.mol |  |
| | PD 145305 Chemical Properties |
| Melting point | 46 °C | | Boiling point | 184-187 °C(Press: 11-12 Torr) | | density | 1.232±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | ≤20mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide | | pka | 3.60±0.10(Predicted) | | form | solution in ethanol. |
| | PD 145305 Usage And Synthesis |
| Uses | PD 145305 is an inactive analog of PD 150606 , a selective inhibitor of calpains (Kis = 0.21 and 0.37 μM for μ- and m-calpain, respectively). It is inactive at concentrations up to 500 μM. | | Biological Activity | pd 145305 is an inactive analog of pd 150606, a potent and selective calpains inhibitor [1].calpain is a class of cytosolic cysteine protease that is activated by elevated intracellular calcium. overactivation of calpain has been implicated in the pathophysiology of several degenerative conditions, including stroke, myocardial ischemia, neuromuscular degeneration, and cataract formation [1].pd 145305 is an inactive analog of pd 150606, a potent and selective calpains inhibitor. pd 150606, an alpha-mercaptoacrylate derivative, inhibited μ-calpain and m-calpain with ki values of 0.21 and 0.37 μm, respectively. pd 145305 was inactive at concentrations up to 500 μm. in human leukemic molt-4 cells, pd150606 inhibited a-spectrin proteolysis in a dose-dependent way and virtually eliminated the formation of the 145-kda fragment at 10 μm, whereas pd145305 did not attenuate a-spectrin breakdown product formation. in fetal rat cerebrocortical cultures subjected to a combination of hypoxia and hypoglycemia, pd150606 significantly inhibited the release of lactate dehydrogenase, whereas pd145305 was ineffective. pd150606, but not pd145305, was found to make cerebral glutamatergic neurons more resistant to hypoxic/hypoglycemic challenge [1]. | | references | [1]. wang kk, nath r, posner a, et al. an alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective. proc natl acad sci u s a. 1996 jun 25;93(13):6687-92. |
| | PD 145305 Preparation Products And Raw materials |
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