Z-ILE-LEU-ALDEHYDE
| 中文名称 | Z-ILE-LEU-ALDEHYDE |
|---|---|
| 中文同义词 | GAMMA-SECRETASE抑制剂(Z-ILE-LEU-ALDEHYDE) |
| 英文名称 | GAMMA-SECRETASE INHIBITOR XII |
| 英文同义词 | Z-ILE-LEU-ALDEHYDE;Z-IL-CHO;GAMMA-SECRETASE INHIBITOR XII;Carbamic acid, N-[(1S,2S)-1-[[[(1S)-1-formyl-3-methylbutyl]amino]carbonyl]-2-methylbutyl]-, phenylmethyl ester;Benzyl ((2S,3S)-3-methyl-1-(((S)-4-methyl-1-oxopentan-2-yl)amino)-1-oxopentan-2-yl)carbamate;Z-IL-CHO;GSI-XII;Γ-SECRETASE INHIBITOR XII;Z-ILE-LEU-ALDEHYDE(Z-IL-CHO; GSI-XII);Z-Ile-Leu-aldehyde(Z-IL-CHO |
| CAS号 | 161710-10-7 |
| 分子式 | C20H30N2O4 |
| 分子量 | 362.46 |
| EINECS号 | |
| 相关类别 | 细胞生物学试剂 |
| Mol文件 | 161710-10-7.mol |
| 结构式 |  |
Z-ILE-LEU-ALDEHYDE 性质
| 沸点 | 545.6±45.0 °C(Predicted) |
|---|---|
| 密度 | 1.074±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 不溶于乙醇；不溶于水； DMSO 中≥10.8 mg/mL |
| 形态 | 固体 |
| 酸度系数(pKa) | 11.14±0.46(Predicted) |
| 颜色 | 白色至米白色 |
Z-Ile-Leu-aldehyde (Z-IL-CHO) 是有效的、竞争性的 γ-secretase 和 notch 的肽醛抑制剂。
Z-Ile-Leu-aldehyde (ILCHO) significantly downregulates Th17-associated cytokine levels in murine Th17 in vitro polarization assays.
Z-Ile-Leu-aldehyde (GSI XII) induces apoptosis of murine MOPC315.BM myeloma cells with high Notch activity.
RT-PCRsup>[1]
| Cell Line: | CD4 + T cells from C57BL/6 mice. |
| Concentration: | 25 μM. |
| Incubation Time: | 24, 48, 72 hours. |
| Result: | DownregulateD RORt and IL-17 mRNA expression. |
Cell Viability Assaysup>[2]
| Cell Line: | MOPC315.BM cells. |
| Concentration: | 0, 12, 15 μM. |
| Incubation Time: | 24-48 h hours. |
| Result: | Reduced viability and induced apoptosis in MOPC315.BM cells |
Z-Ile-Leu-aldehyde (GSI XII, 10 mg/kg, Intraperitoneally either for 14 days) controls myeloma bone disease mainly by targeting Notch in MM cells and possibly in osteoclasts in their microenvironment.
| Animal Model: | MOPC315.BM mouse model. |
| Dosage: | 10 mg/kg. |
| Administration: | Intraperitoneally either for 14 days. |
| Result: |
Reduces myeloma-specific paraprotein levels in the MOPC315.BM model.
Diminished osteolytic lesions in the MOPC315.BM mice. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-12465 | Z-Ile-Leu-aldehyde | 1 mg | 1600元 | |
| 2024/04/30 | HY-12465 | Z-ILE-LEU-ALDEHYDE Z-Ile-Leu-aldehyde | 161710-10-7 | 2mg | 2333元 |