| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:bpV(pic)
CAS:148556-27-8
Purity:>=95% V basis Package:5mg, 25mg Remarks:SML0885
|
| Company Name: |
Shanghai EFE Biological Technology Co., Ltd.
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| Tel: |
021-65675885 18964387627 |
| Email: |
info@efebio.com |
| Products Intro: |
Product Name:bpV(pic) (potassium hydrate)
CAS:148556-27-8
Purity:96% (51V-NMR) Package:5mg;25mg
|
| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:bpV(pic) potassium hydrate
CAS:148556-27-8
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing1@energy-chemical.com |
| Products Intro: |
Product Name:bpV(pic)
CAS:148556-27-8
Purity:NULL Package:10mg;5mg;25mg;5mg Remarks:NULL
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| | BPV(PIC) Basic information |
| Product Name: | BPV(PIC) | | Synonyms: | DIPOTASSIUM BISPEROXO(PICOLINATO)OXOVANADATE (V);BPV(PIC);Dipotassium bisperoxo (picolinato) oxovanadate (V) dihydrate;Dipotassium Bisperoxovanadium(pic) dihydrate;K2 [VO(O2)2C6H4NO2] 2 H2O;bpV(pic) (potassium hydrate) | | CAS: | 148556-27-8 | | MF: | C6H8K2NO9V-3 | | MW: | 367.26712 | | EINECS: | | | Product Categories: | | | Mol File: | 148556-27-8.mol |  |
| | BPV(PIC) Chemical Properties |
| storage temp. | -20°C | | solubility | H2O: soluble20mg/mL, clear | | form | powder | | color | faint yellow to dark yellow |
| Hazard Codes | Xi | | Risk Statements | 36/38 | | Safety Statements | 26 | | WGK Germany | 3 |
| | BPV(PIC) Usage And Synthesis |
| Uses | bpV(pic) is a potent protein PTP inhibitor. | | Uses | bpV(pic) is a bisperoxovanadium (bpV) compound that inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 = 31 nM). It also inhibits the vascular endothelial PTP, PTP-β (IC50 = 12.7 μM), and PTP-1βB (IC50 = 61 μM). bpV(pic) is also known to be an insulin mimetic capable of activating the insulin receptor kinase of cultured hepatoma cells, stimulating lipogenesis in adipocytes, and inhibiting the dephosphorylation of autophosphorylated insulin receptors and epidermal growth factor receptors of rat liver endosomes. | | Biochem/physiol Actions | bpV(pic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for phosphatase and tensin homolog (PTEN), a tumour suppressor phosphatase involved in cell cycle regulation. IC50 values for bpV(pic) are 31 nM for PTEN compared to 12.7 μM for PTPβ and 61 μM for PTP-1β. bpV(pic) can also act as an insulin mimetic and activate insulin receptor kinase (IRK). |
| | BPV(PIC) Preparation Products And Raw materials |
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