| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:JNc-440
CAS:1119503-63-7
Purity:98% Package:500 mg
|
| Company Name: |
Nantong QuanYi Biotechnology Co., Ltd
|
| Tel: |
0513-66337626 18051384581 |
| Email: |
sales@chemhifuture.com |
| Products Intro: |
Product Name:JNc-440
CAS:1119503-63-7
Purity:98%+ HPLC Package:10mg，500mg，1g，2g，5g，10g，more
|
| Company Name: |
PHARMEKS Ltd.
|
| Tel: |
+7 (495) 702-9648 |
| Email: |
sales@pharmeks.com |
| Products Intro: |
CAS:1119503-63-7
Package:5μmol Remarks:C26H24N4O3
|
| Company Name: |
Interbioscreen Ltd.
|
| Tel: |
+7 (49) 6524-0091 |
| Email: |
screen@ibscreen.chg.ru |
| Products Intro: |
CAS:1119503-63-7
Purity:95% Package:1mg Remarks:C26H24N4O3
|
|
| | N-{3-[(diphenylacetyl)amino]propyl}-4-oxo-3,4-dihydro-2-quinazolinecarboxamide Basic information |
| | N-{3-[(diphenylacetyl)amino]propyl}-4-oxo-3,4-dihydro-2-quinazolinecarboxamide Chemical Properties |
| density | 1.26±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | form | Solid | | pka | 10.06±0.20(Predicted) | | color | White to off-white |
| | N-{3-[(diphenylacetyl)amino]propyl}-4-oxo-3,4-dihydro-2-quinazolinecarboxamide Usage And Synthesis |
| Biological Activity | JNc-440 is a potent antihypertensive agent. JNc-440 can enhance the interaction of TRPV4 and Ca2+-activated potassium channel 3 (KCa2.3) in endothelial cells. JNc-440 can also enhance vasodilation, and exerted antihypertensive effects in mice[1].
JNc-440 (1 mg/kg; IV; single dosage) improves endothelium-dependent relaxation in small resistance arteries and to lower blood pressure[1]. | | References | [1]. He D, et al. Treatment of hypertension by increasing impaired endothelial TRPV4-KCa2.3 interaction. EMBO Mol Med. 2017 Nov;9(11):1491-1503. |
| | N-{3-[(diphenylacetyl)amino]propyl}-4-oxo-3,4-dihydro-2-quinazolinecarboxamide Preparation Products And Raw materials |
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