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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
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025-66028182 18626450290 |
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yftan@aikonchem.com |
| Products Intro: |
Product Name:(4'-METHYLBIPHENYL-3-YL)-METHANOL
CAS:89951-79-1
Purity:95+% Package:1g;5g;10g
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| | (4'-METHYLBIPHENYL-3-YL)-METHANOL Basic information | | Synthesis |
| Product Name: | (4'-METHYLBIPHENYL-3-YL)-METHANOL | | Synonyms: | (4'-METHYLBIPHENYL-3-YL)-METHANOL;(4'-METHYL[1,1'-BIPHENYL]-3-YL)METHANOL;AKOS BAR-1215;RARECHEM AL BD 1348;3-(4-Tolyl)benzyl alcohol;4'-Methyl[1,1'-biphenyl]-3-methanol;(4'-Methyl-[1,1'-biphenyl]-3-yl)methanol | | CAS: | 89951-79-1 | | MF: | C14H14O | | MW: | 198.26 | | EINECS: | | | Product Categories: | pharmacetical | | Mol File: | 89951-79-1.mol |  |
| | (4'-METHYLBIPHENYL-3-YL)-METHANOL Chemical Properties |
| Boiling point | 346.3±11.0 °C(Predicted) | | density | 1.072±0.06 g/cm3(Predicted) | | pka | 14.31±0.10(Predicted) |
| | (4'-METHYLBIPHENYL-3-YL)-METHANOL Usage And Synthesis |
| Synthesis |  To a suspension of potassium flfluoride (350 mg, 6.0 mmol, spray dried) in DMF (50 mL) were added ethyldiflfluoro-(4-methyl)silane (560 mg, 3.0 mmol), 3-iodobenzyl alcohol (250 mg, 2.0 mmol), and (η3 -C3H5PdCl)2 (37 mg, 0.1 mmol). The resulting mixture was stirred at 100 °C for 15 h, cooled to room temperature, poured into saturated aqueous sodium bicarbonate solution, and extracted with diethyl ether (3 × 20 mL). The combined ethereal layer was then dried over magnesium sulfate. The solvent was removed under reduced pressure. The crude material was purifified by silica gel chromatography eluting a mixture of hexane:EtOAc (5:1) to give 340 mg (86%) of 3-hydroxymethyl-4´-methylbiphenyl as a colorless solid.Reference: Hatanaka, Y; Goda, K.; Okahara, Y.; Hiyama, T. Tetrahedron 1994, 50, 8301−8316. |
| | (4'-METHYLBIPHENYL-3-YL)-METHANOL Preparation Products And Raw materials |
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