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3,4,5-trimethoxy-N-[[4-methyl-3-[(4-phenylbenzoyl)amino]phenyl]carbamothioyl]benzamide

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3,4,5-trimethoxy-N-[[4-methyl-3-[(4-phenylbenzoyl)amino]phenyl]carbamothioyl]benzamide Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354
Email: support@targetmol.com
Products Intro: Product Name:MRT-81
CAS:1263132-08-6
Package:1 mg；10 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:MRT-81
CAS:1263132-08-6
Purity:98% Package:$260.9/5mg;$415.9/10mg;$830.9/25mg;$1320.9/50mg;Bulk package Remarks:98%
Company Name: Tianjin Kailiqi Biotechnology Co., Ltd.  
Tel: 15076683720
Email: klq@cw-bio.com
Products Intro: Product Name:MRT-81
CAS:1263132-08-6
Purity:≥98% Package:1g,5g,10g,25g根据客户需要分装 Remarks:Not For Human Use, Lab Use Only.
Company Name: ShangHai Biochempartner Co.,Ltd  
Tel: 17754423994 17754423994
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Products Intro: Product Name:MRT-81
CAS:1263132-08-6
Purity:98% HPLC LCMS Package:100mg;500mg;1g
Company Name: DC Chemicals  
Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Products Intro: Product Name:MRT-81
CAS:1263132-08-6
Purity:98% HPLC Package:100mg，250mg，1g
3,4,5-trimethoxy-N-[[4-methyl-3-[(4-phenylbenzoyl)amino]phenyl]carbamothioyl]benzamide Basic information
Product Name:3,4,5-trimethoxy-N-[[4-methyl-3-[(4-phenylbenzoyl)amino]phenyl]carbamothioyl]benzamide
Synonyms:MRT-81;3,4,5-trimethoxy-N-[[4-methyl-3-[(4-phenylbenzoyl)amino]phenyl]carbamothioyl]benzamide;Smo,Smoothened,human,C3H10T1/2 cells,inhibit,Shh-light2 cells,rodent,BODIPY-cyclopamine,MRT81,MRT-81,rat granule cell precursors,Inhibitor,MRT 81;[1,1'-Biphenyl]-4-carboxamide, N-[2-methyl-5-[[thioxo[(3,4,5-trimethoxybenzoyl)amino]methyl]amino]phenyl]-;N-(2-Methyl-5-(3-(3,4,5-trimethoxybenzoyl)thioureido)phenyl)-[1,1'-biphenyl]-4-carboxamide;N-(2-Methyl-5-(3-(3,4,5-trimethoxybenzoyl)thioureido)phenyl)-[1,1'-biphenyl]-4-carboxamide
CAS:1263132-08-6
MF:C31H29N3O5S
MW:555.64
EINECS:
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Mol File:1263132-08-6.mol
3,4,5-trimethoxy-N-[[4-methyl-3-[(4-phenylbenzoyl)amino]phenyl]carbamothioyl]benzamide Structure
3,4,5-trimethoxy-N-[[4-methyl-3-[(4-phenylbenzoyl)amino]phenyl]carbamothioyl]benzamide Chemical Properties
density 1.289±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
pka8.09±0.70(Predicted)
form Solid
color White to light yellow
Safety Information
MSDS Information
3,4,5-trimethoxy-N-[[4-methyl-3-[(4-phenylbenzoyl)amino]phenyl]carbamothioyl]benzamide Usage And Synthesis
Biological ActivityMRT-81 is a potent antagonist of human and rodent smoothened Smo receptors, with an IC50 value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 can be used for the research of cancer[1]. MRT-81 inbihits the differentiation of the mesenchymal pluripotent C3H10T1/2 cells into alkaline phosphatasepositive osteoblasts induced by the Smo agonist SAG (0.1 μM), with an IC50 value of 64 nM[1].MRT-81 (1-1000 nM) is a potent antagonist of SAG (0.01 μM)-induced proliferation of rat granule cell precursors (GCPs) with an IC50 less than 10 nM[1].MRT-81 (0, 0.1, 1, 10, 30, 100, 300, 1000 nM; 2 h; 37 °C) blocks BODIPY-cyclopamine (5 nM) binding to hSmo in a dose-dependent manner with an IC50 of 63 nM in HEK-hSmo cells[1].
References[1]. Solinas A, et al. Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity. J Med Chem. 2012 Feb 23;55(4):1559-71.
3,4,5-trimethoxy-N-[[4-methyl-3-[(4-phenylbenzoyl)amino]phenyl]carbamothioyl]benzamide Preparation Products And Raw materials
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