| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:TS 155-2
CAS:1314486-37-7
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
MedBioPharmaceutical Technology Inc
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| Tel: |
021-69568360 18916172912 |
| Email: |
order@med-bio.cn |
| Products Intro: |
Product Name:TS 155-2
CAS:1314486-37-7
Purity:98% Package:1mg; 5mg Remarks:Medbio
|
| Company Name: |
ApexBio Technology
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| Tel: |
+ 1-832-696-8203 |
| Email: |
sales@apexbt.com |
| Products Intro: |
Product Name:TS 155-2
CAS:1314486-37-7
|
| Company Name: |
Cayman Chemical Company
|
| Tel: |
(800) 364-9897 |
| Email: |
cayman@caymanchem.com |
| Products Intro: |
Product Name:TS 155-2
CAS:1314486-37-7
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| | TS 155-2 Basic information |
| Product Name: | TS 155-2 | | Synonyms: | 2-Butenedioic acid (2E)-, 1-[(2R,4R,5S,6R)-tetrahydro-2-hydroxy-2-[(1S,2R,3S)-2-hydroxy-3-[(2R,3S,4E,6E,9S,10S,11R,12E,14E)-10-hydroxy-3-methoxy-7,9,11,13,15-pentamethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-5-methyl-6-(1-methylethyl)-2H-pyran-4-yl] ester;2E-butenedioicacid-1-[(2R,4R,5S,6R)-tetrahydro-2-hydroxy-2-[(1S,2R,3S)-2-hydroxy-3-[(2R,3S,4E,6E,9S,10S,11R,12E,14E)-10-hydroxy-3-methoxy-7,9,11,13,15-pentamethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-5-methyl-6-(1-methylethyl)-2H-pyran-4-yl]ester | | CAS: | 1314486-37-7 | | MF: | C39H60O11 | | MW: | 704.89 | | EINECS: | | | Product Categories: | | | Mol File: | 1314486-37-7.mol |  |
| | TS 155-2 Chemical Properties |
| Boiling point | 824.6±65.0 °C(Predicted) | | density | 1.16±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | solid | | pka | 3.28±0.10(Predicted) |
| | TS 155-2 Usage And Synthesis |
| Biological Activity | ts 155-2, is a macrocyclic lactone related to hygrolidin, is produced by a different streptomyces species found in oil. it blocks thrombin-evoked calcium (ca2+) entry into cells. ts155-2 exerts hypotensive, anti-platelet, anti-ischaemic and anti-inflammatory activity showed on the original patent, however, no literature investigation of ts155-2 is available.a rapid increase in cytosolic ca2+ is related to the signal transduction events following the induction of thrombin in a wide range of cell types which include fibroblasts, platelets, megakaryocytes, endothelium and smooth muscle. thrombin-stimulated ca2+ mobilization has been shown to be involved in both ca2+ release from internal storage sites and ca2+influx and has been extensively studied in human platelets. thrombin triggers phospholipase c resulting in the rapid generation of inositol 1,4,5-trisphosphate (ip3), which elicits the release of ca2+ from ip3-sensitive stores. however, the thrombin-induced ca2+ influx is still an area of contention [1]. | | references | [1]. somasundaram, b., mason, m., & mahaut-smith, m. thrombin-dependent calcium signalling in single human erythroleukaemia cells. the journal of physiology.1997;501(3):485-495. |
| | TS 155-2 Preparation Products And Raw materials |
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