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| | IITZ-01 Basic information |
| Product Name: | IITZ-01 | | Synonyms: | IITZ-01;AUTOPHAGY INHIBITOR;IITZ 01;IITZ01;Autophagy inhibitor IITZ-01;AUTOPHAGY INHIBITOR IITZ-01;IITZ 01;IITZ01;CS-2857;1,3,5-Triazine-2,4-diamine, N2-[4-(1H-benzimidazol-2-yl)phenyl]-N4-(4-fluorophenyl)-6-(4-morpholinyl)-;N-[4-(1H-Benzimidazol-2-yl)phenyl]-N'-(4-fluorophenyl)-6-(4-morpholinyl)-1,3,5-triazine-2,4-diamine;Phosphoinositide 3-kinase,IITZ 01,IITZ01,Apoptosis,IITZ-01,Autophagy,inhibit,Inhibitor,PI3K | | CAS: | 1807988-47-1 | | MF: | C26H23FN8O | | MW: | 482.51 | | EINECS: | | | Product Categories: | API | | Mol File: | 1807988-47-1.mol |  |
| | IITZ-01 Chemical Properties |
| Boiling point | 747.0±70.0 °C(Predicted) | | density | 1.420±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | solubility | DMSO:100.0(Max Conc. mg/mL);207.24(Max Conc. mM) | | pka | 11.55±0.10(Predicted) | | form | Solid | | color | White to off-white |
| | IITZ-01 Usage And Synthesis |
| Biological Activity | IITZ-01 is a potent lysosomal autophagy inhibitor with antitumor activity, with IC50 value of 2.62 μM for PI3Kγ. | | in vivo | IITZ-01 (45 mg/kg, ip every alternate day for 4 weeks) inhibits average breast tumor growth when compared with control from third day of treatment in triple-negative breast tumor models in mice. | Animal Model: | MDA-MB-231 (TNBC)/green fluorescent protein (GFP) orthotropic breast cancer xenografts were developed in CrTac:NCr- Foxn nu BALB/c female nude mice. | | Dosage: | 45 mg/kg. | | Administration: | Intraperitoneal every alternate day for 4 weeks. | | Result: | Inhibited average breast tumor growth when compared with control from third day of treatment. | | | target | | PI3Kγ 2.62 μM (IC 50 ) | Autophagy < /span> | |
| | IITZ-01 Preparation Products And Raw materials |
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