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ShangHai Biochempartner Co.,Ltd
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| Products Intro: |
Product Name:VU0453595
CAS:1432436-13-9
Purity:98% HPLC LCMS Package:100MG;1G
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| Company Name: |
Shanghai Chaolan Chemical Technology Center
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| Tel: |
QQ:65489617 15618227136 |
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info@SuperLan-chem.com |
| Products Intro: |
Product Name:vu0453595
CAS:1432436-13-9
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
|
| Company Name: |
Shanghai SuperLan Chemcial Technique Centre
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| Tel: |
021-2022843681 15618226720 |
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chaolaichem@foxmail.com |
| Products Intro: |
Product Name:vu0453595
CAS:1432436-13-9
Purity:95% Package:1G,5G,10G,50G,100G,1KG
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| | VU0453595 Basic information |
| Product Name: | VU0453595 | | Synonyms: | VU0453595;VU453595;Muscarinic acetylcholine receptor,modulator,systemically,allosteric,mAChR,PAM,positive,VU0453595,inhibit,schizophrenia,Inhibitor;5H-Pyrrolo[3,4-b]pyridin-5-one, 6-[[2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl]methyl]-6,7-dihydro- | | CAS: | 1432436-13-9 | | MF: | C18H15FN4O | | MW: | 322.34 | | EINECS: | | | Product Categories: | | | Mol File: | 1432436-13-9.mol |  |
| | VU0453595 Chemical Properties |
| Boiling point | 552.8±50.0 °C(Predicted) | | density | 1.35±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 100 mg/mL (310.23 mM; Need ultrasonic) | | pka | 2.98±0.20(Predicted) |
| | VU0453595 Usage And Synthesis |
| Biological Activity | VU0453595 is a highly selective, systemically active M1 positive allosteric modulator (PAM, EC50=2140 nM) for the research of schizophrenia[1][2].
Application of M1 PAM VU0453595 (3 μM) induces a transient increase in excitability of medium spiny neurons (MSNs)[3].
VU0453595 potentiates M1-mediated muscarinic long-term depression (mLTD)[1].VU0453595 (1-10 mg/kg; i.p.) reverses behavioral deficits induced by repeated phencyclidine (PCP) administration[1]. | | References | [1]. A Ghoshal, et al. Potentiation of M1 Muscarinic Receptor Reverses Plasticity Deficits and Negative and Cognitive Symptoms in a Schizophrenia Mouse Model. Neuropsychopharmacology. 2016 Jan;41(2):598-610. [2]. Sean P Moran, et al. M1-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition. Neuropsychopharmacology. 2018 Jul;43(8):1763-1771. [3]. Xiaohui Lv, et al. M1 muscarinic activation induces long-lasting increase in intrinsic excitability of striatal projection neurons. Neuropharmacology. 2017 May 15;118:209-222. |
| | VU0453595 Preparation Products And Raw materials |
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