ADU-S100 DISODIUM SALT
中文名称 | ADU-S100 DISODIUM SALT |
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中文同义词 | 化合物 T10252;ADU-S100二钠盐 |
英文名称 | c[A(2',5')pS[Rp]-A(3',5')pS[Rp]] / Rp,Rp-2'3'-c-diAMPSS |
英文同义词 | c[A(2',5')pS[Rp]-A(3',5')pS[Rp]] / Rp,Rp-2'3'-c-diAMPSS;ADU-S100 (MIW815);ADU-S100 disodium salt;ML RR-S2 CDA disodium salt;MIW815 disodium salt;ML RR-S2 CDA Sodium Salt;ADUS100 sodium;ADUS100 disodium salt,ADU S100 disodium salt,ADU-S-100 disodium salt |
CAS号 | 1638750-95-4 |
分子式 | C20H25N10NaO10P2S2 |
分子量 | 714.54 |
EINECS号 | |
相关类别 | 制剂-激动剂 |
Mol文件 | 1638750-95-4.mol |
结构式 | ![]() |
ADU-S100 DISODIUM SALT 性质
储存条件 | Store at -20°C |
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形态 | 固体 |
颜色 | 白色至米白色 |
水溶解性 | Water: 100 mg/mL (136.15 mM; ultrasonic and adjust pH to 7 with NaOH) |
STING
ADU-S100 shows enhanced type I IFN production over CDA in THP-1 human monocytes. In contrast, the dithio, mixed-linkage cyclic dinucleotide (CDN) derivatives (ML RR-CDA, ML RR-S2 CDG, and ML RR-S2 cGAMP) potently activate all five hSTING alleles, including the refractory hSTING REF and hSTING Q alleles. ADU-S100 induces the highest expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and MCP-1 on a molar equivalent basis, as compared to endogenous ML cGAMP and the TLR3 agonist poly I:C. ADU-S100 is also found to induce aggregation of STING and induce phosphorylation of TBK1 and IRF3 in mouse bone marrow macrophage (BMM). ADU-S100 induces significantly higher levels of IFN-α when compared to ML cGAMP.
ADU-S100 shows higher anti-tumor control than the endogenous ML cGAMP. A dose response of the ADU-S100 compound is performed in B16 tumor-bearing mice, which identifies an optimal antitumor dose level that also elicites maximum tumor antigen-specific CD8 + T cell responses, and improves long-term survival to 50%.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-12885A | ADU-S100 DISODIUM SALT ADU-S100 disodium salt | 1638750-95-4 | 1mg | 3300元 |
2023/03/20 | HY-12885A | ADU-S100 DISODIUM SALT ADU-S100 disodium salt | 1638750-95-4 | 5mg | 12000元 |