| Company Name: |
Creative Peptides
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info@creative-peptides.com |
| Products Intro: |
Product Name:Huwentoxin XVI
CAS:1600543-88-1
Purity:>98% Package:1g; 10g;100g;1kg Remarks:Peptide Inhibitors
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| Company Name: |
Hangzhou Peptidego Biotech Co.,Ltd.
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| Tel: |
0571-87213919 |
| Email: |
eric@peptidego.com |
| Products Intro: |
Product Name:Huwentoxin XVI
CAS:1600543-88-1
Purity:95% or 98% HPLC Package:1mg；5mg；10mg；50mg；100mg,1g or according to customer's detail requirement.
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| | HUWENTOXIN XVI Basic information |
| Product Name: | HUWENTOXIN XVI | | Synonyms: | HUWENTOXIN XVI;Cys15-Cys36);Cys8-Cys21;H-Cys-Ile-Gly-Glu-Gly-Val-Pro-Cys-Asp-Glu-Asn-Asp-Pro-Arg-Cys-Cys-Ser-Gly-Leu-Val-Cys-Leu-Lys-Pro-Thr-Leu-His-Gly-Ile-Trp-Tyr-Lys-Ser-Tyr-Tyr-Cys-Tyr-Lys-Lys-OH(Disulfide bridge：Cys1-Cys16 | | CAS: | 1600543-88-1 | | MF: | C196H292N50O56S6 | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![HUWENTOXIN XVI Structure]() |
| | HUWENTOXIN XVI Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble to 1 mg/ml in H2O | | form | solid | | color | White | | Water Solubility | Soluble to 1 mg/ml in water |
| | HUWENTOXIN XVI Usage And Synthesis |
| Biological Activity | huwentoxin xvi(hwtx-xvi ) is composed of 39 amino acid residues including six cysteines. hwtx-xvi is a novel neurotoxin from the venom of chinese tarantula o. huwena. and specificially block n-type calcium channels. [1]n-type calcium channels are often highly expressed both in dorsal root ganglia cell bodies and in the synaptic terminals projecting to dorsal horn of the spinal cord n-type calcium channels play important roles in the control of neurotransmission release and transmission of pain signals to the central nervous system.[2]electrophysiological assay indicated that hwtx-xvi specifically inhibited n-type calcium channels in rat dorsal root ganglion cells. hwtx-xvi specifically inhibits gvia sensitive, n-type calcium channels in rat drg cells.[1]hwtx-xvi could almost completely block the twitch response of rat vas deferens to low-frequency electrical stimulation. hwtx-xvi ‘s analgesic effects, non-toxic and complete reversibility make it an interesting tool for developing novel drugs for the treatment of n-type calcium channel-related diseases.[1,2] | | references | [1] deng m, luo x, xiao y etal. , huwentoxin-xvi, an analgesic, highly reversible mammalian n-type calcium channel antagonist from chinese tarantula ornithoctonus huwena. neuropharmacology. 2014 apr;79:657-67.
[2] liu z, dai j, dai l etal. , function and solution structure of huwentoxin-x, a specific blocker of n-type calcium channels, from the chinese bird spider ornithoctonus huwena. j biol chem. 2006 mar 31;281(13):8628-35. |
| | HUWENTOXIN XVI Preparation Products And Raw materials |
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