| Company Name: |
BOC Sciences
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info@bocsci.com |
| Products Intro: |
Product Name:GPBAR-A
CAS:877052-79-4
Purity:≥98% by HPLC Remarks:GPBAR-A is a GPBA receptor agonist. GPBAR-A increases GLP-1 secretion from intestinal cultures.
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| Company Name: |
MedBioPharmaceutical Technology Inc
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| Tel: |
021-69568360 18916172912 |
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order@med-bio.cn |
| Products Intro: |
Product Name:GPBAR-A
CAS:877052-79-4
Purity:98% Package:50mg; 10mg Remarks:Medbio
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| Company Name: |
Energy Chemical
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021-58432009 400-005-6266 |
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marketing@energy-chemical.com |
| Products Intro: |
Product Name:GPBAR-A >=98% (HPLC)
CAS:877052-79-4
Purity:NULL Package:25mg;5mg Remarks:NULL
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| | GPBAR-A Basic information |
| Product Name: | GPBAR-A | | Synonyms: | GPBAR-A;4-[[3,5-Bis(trifluoromethyl)phenyl]methyl]-6-(2-fluorophenyl)-4,5-dihydro-pyrido[3,2-f]-1,4-oxazepin-3(2H)-one;Pyrido[3,2-f]-1,4-oxazepin-3(2H)-one, 4-[[3,5-bis(trifluoromethyl)phenyl]methyl]-6-(2-fluorophenyl)-4,5-dihydro-;GPBAR-A >=98% (HPLC) | | CAS: | 877052-79-4 | | MF: | C23H15F7N2O2 | | MW: | 484.37 | | EINECS: | | | Product Categories: | | | Mol File: | 877052-79-4.mol |  |
| | GPBAR-A Chemical Properties |
| solubility | <9.69mg/ml in ethanol; <48.44mg/ml in DMSO | | form | solid | | color | Off-white |
| | GPBAR-A Usage And Synthesis |
| Uses | GPBAR-A is a GPBA receptor (TGR5) agonist. | | Biological Activity | gpbar-a is an agonist of bile acid receptor gpbar1 [1].the g protein-coupled bile acid receptor 1 (gpbar1, tgr5) is a plasma membrane-bound receptor for bile acids. tgr5 is involved in gallstone formation and is expressed in the epithelium of human gallbladders [2].gpbar-a is an agonist of bile acid receptor gpbar1. in glutag cells, gpbar-a stimulated glucagon-like peptide (glp-1) release. in primary colonic cultures, gpbar-a increased glp-1 release by 4.2-fold. in upper small intestinal cultures, gpbar-a increased glp-1 release by 2.6-fold. in glutag cells, gpbar-a increased camp concentration by 57%. also, gpbar-a increased calcium in 56/149 cells and caused the mean response by 1.3-fold. in the presence of glucose, gpbar-a increased calcium in 148/149 cells and caused the mean response by 2.6-fold. in the presence of diazoxide (the katp channel opener, 340 μm) and 70 mm kcl, gpbar-a also increased glp-1 secretion. in colonic and small intestinal cultures, gpbar-a increased the glp-1 secretion by 2.4-fold and 1.5-fold. the glp-1 secretion mediated by gpbar-a was independent on katp channel closure [1]. | | storage | Store at -20°C | | references | [1]. parker he, wallis k, le roux cw, et al. molecular mechanisms underlying bile acid-stimulated glucagon-like peptide-1 secretion. br j pharmacol, 2012, 165(2): 414-423.
[2]. keitel v, cupisti k, ullmer c, et al. the membrane-bound bile acid receptor tgr5 is localized in the epithelium of human gallbladders. hepatology, 2009, 50(3): 861-870. |
| | GPBAR-A Preparation Products And Raw materials |
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