Company Name: |
BOC Sciences
|
Tel: |
|
Email: |
info@bocsci.com |
Products Intro: |
Product Name:GPBAR-A CAS:877052-79-4 Purity:≥98% by HPLC Remarks:GPBAR-A is a GPBA receptor agonist. GPBAR-A increases GLP-1 secretion from intestinal cultures.
|
Company Name: |
MedBioPharmaceutical Technology Inc
|
Tel: |
021-69568360 18916172912 |
Email: |
order@med-bio.cn |
Products Intro: |
Product Name:GPBAR-A CAS:877052-79-4 Purity:98% Package:50mg; 10mg Remarks:Medbio
|
Company Name: |
Energy Chemical
|
Tel: |
021-58432009 400-005-6266 |
Email: |
marketing@energy-chemical.com |
Products Intro: |
Product Name:GPBAR-A >=98% (HPLC) CAS:877052-79-4 Purity:NULL Package:25mg;5mg Remarks:NULL
|
|
| GPBAR-A Basic information |
Product Name: | GPBAR-A | Synonyms: | GPBAR-A;4-[[3,5-Bis(trifluoromethyl)phenyl]methyl]-6-(2-fluorophenyl)-4,5-dihydro-pyrido[3,2-f]-1,4-oxazepin-3(2H)-one;Pyrido[3,2-f]-1,4-oxazepin-3(2H)-one, 4-[[3,5-bis(trifluoromethyl)phenyl]methyl]-6-(2-fluorophenyl)-4,5-dihydro-;GPBAR-A >=98% (HPLC) | CAS: | 877052-79-4 | MF: | C23H15F7N2O2 | MW: | 484.37 | EINECS: | | Product Categories: | | Mol File: | 877052-79-4.mol | ![GPBAR-A Structure](CAS/20200515/GIF/877052-79-4.gif) |
| GPBAR-A Chemical Properties |
solubility | <9.69mg/ml in ethanol; <48.44mg/ml in DMSO | form | solid | color | Off-white |
| GPBAR-A Usage And Synthesis |
Uses | GPBAR-A is a GPBA receptor (TGR5) agonist. | Biological Activity | gpbar-a is an agonist of bile acid receptor gpbar1 [1].the g protein-coupled bile acid receptor 1 (gpbar1, tgr5) is a plasma membrane-bound receptor for bile acids. tgr5 is involved in gallstone formation and is expressed in the epithelium of human gallbladders [2].gpbar-a is an agonist of bile acid receptor gpbar1. in glutag cells, gpbar-a stimulated glucagon-like peptide (glp-1) release. in primary colonic cultures, gpbar-a increased glp-1 release by 4.2-fold. in upper small intestinal cultures, gpbar-a increased glp-1 release by 2.6-fold. in glutag cells, gpbar-a increased camp concentration by 57%. also, gpbar-a increased calcium in 56/149 cells and caused the mean response by 1.3-fold. in the presence of glucose, gpbar-a increased calcium in 148/149 cells and caused the mean response by 2.6-fold. in the presence of diazoxide (the katp channel opener, 340 μm) and 70 mm kcl, gpbar-a also increased glp-1 secretion. in colonic and small intestinal cultures, gpbar-a increased the glp-1 secretion by 2.4-fold and 1.5-fold. the glp-1 secretion mediated by gpbar-a was independent on katp channel closure [1]. | storage | Store at -20°C | references | [1]. parker he, wallis k, le roux cw, et al. molecular mechanisms underlying bile acid-stimulated glucagon-like peptide-1 secretion. br j pharmacol, 2012, 165(2): 414-423. [2]. keitel v, cupisti k, ullmer c, et al. the membrane-bound bile acid receptor tgr5 is localized in the epithelium of human gallbladders. hepatology, 2009, 50(3): 861-870. |
| GPBAR-A Preparation Products And Raw materials |
|