| Company Name: |
Creative Peptides
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| Email: |
info@creative-peptides.com |
| Products Intro: |
Product Name:P11
CAS:848644-86-0
Purity:>98% Package:1g; 10g;100g;1kg Remarks:Peptide Inhibitors
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| Product Name: | P11 | | Synonyms: | L-Lysinamide, L-histidyl-L-seryl-L-α-aspartyl-L-valyl-L-histidyl- (9CI);P11 ( (trifluoroacetate salt) | | CAS: | 848644-86-0 | | MF: | C30H48N12O9 | | MW: | 720.79 | | EINECS: | | | Product Categories: | | | Mol File: | 848644-86-0.mol |  |
| Boiling point | 1380.0±65.0 °C(Predicted) | | density | 1.381±0.06 g/cm3(Predicted) | | storage temp. | -20°C, protect from light | | solubility | Soluble to 1 mg/ml in 20% acetonitrile - 0.1% acetic acid | | form | Powder | | pka | 4.17±0.10(Predicted) | | color | White to off-white | | Sequence | H-His-Ser-Asp-Val-His-Lys-NH2 |
| Uses | P11 is a useful building block in the synthesis of various pharmaceuticals | | Enzyme inhibitor | This potent PDZ motif-containing anti-angiogenic agent (FW = 720.78
g/mol; CAS 848644-86-0; Sequence: HSDVHK-NH2) targets the integrin
αvβ3-vitronectin interaction, blocking proliferation and inducing apoptosis in
human vascular endothelial cells (HUVECs). Arg-Gly-Asp (or RGD)
binding-site recognition by P11 is site-specific, showing a strong
antagonism against αvβ3-vitronectin interaction, IC50 = 26 nM. The
binding orientation of docked P11 in αvβ3 is similar to that for RGD,
suggesting a divalent metal-ion coordination is a common driving force for
the formation of both SDV·αvβ3 and RGD·αvβ3 complexes. P11 appears to
inhibit b-Fibroblast Growth Factor (or bFGF) -induced HUVEC
proliferation via mitogen-activated protein kinase kinase and extracellular-
signal regulated kinase inhibition as well as p53-mediated apoptosis related
with activation of caspases. (Note: Consisting of 80-90 amino-acids in
far-flung signaling proteins and binding to short C-terminal regions in
protein interaction partners, “PDZ” is an acronym that includes the first
letters of Post-synaptic density protein (PSD95), Drosophila Dlg1 tumor
suppressor, and Zonula occludens-1 protein (zo-1), the first proteins
discovered to share this domain.) |
| | P11 Preparation Products And Raw materials |
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