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| | CH7057288 Basic information |
| Product Name: | CH7057288 | | Synonyms: | CH7057288;4-Pyridinecarboxamide, 2-[2-[6,11-dihydro-6,6-dimethyl-8-[(methylsulfonyl)amino]-11-oxobenzo[b]naphtho[2,3-d]furan-3-yl]ethynyl]-N-(1,1-dimethylethyl)-6-methyl-;Inhibitor,Trk Receptor,CH7057288,inhibit,Tropomyosin related kinase receptor,CH 7057288,CH-7057288 | | CAS: | 2095616-82-1 | | MF: | C32H31N3O5S | | MW: | 569.67 | | EINECS: | | | Product Categories: | | | Mol File: | 2095616-82-1.mol |  |
| | CH7057288 Chemical Properties |
| density | 1.35±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO:34.0(Max Conc. mg/mL);59.68(Max Conc. mM) | | form | Solid | | pka | 6.89±0.40(Predicted) | | color | Off-white to yellow |
| | CH7057288 Usage And Synthesis |
| Biological Activity | CH7057288 is a potent and selective TRK inhibitor with IC50 values of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB and TRKC, respectively. | | in vitro | In cell-free kinase assays, CH7057288 has selective inhibitory activity against TRKA, TRKB and TRKC, and inhibits the proliferation of cells containing TRK fusions. It inhibits MAPK and E2F signaling pathways. | | target | | Target | Value | TrkA
(Cell-free assay) | 1.1 nM | TrkC
(Cell-free assay) | 5.1 nM | < td style="border-bottom: 1px dotted #ccc;padding: 5px;"> TrkB
(Cell-free assay) 7.8 nM |
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| | CH7057288 Preparation Products And Raw materials |
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