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| | DJ-V159 Basic information |
| Product Name: | DJ-V159 | | Synonyms: | DJ-V159;DJ-V159;DJ-V 159;1,3-Benzenedicarboxamide, N1,N3-bis[4-cyano-3-(trifluoromethyl)phenyl]-;DJV159,Inhibitor,Androgen Receptor,inhibit,DJ V 159 | | CAS: | 2253744-53-3 | | MF: | C24H12F6N4O2 | | MW: | 502.37 | | EINECS: | 604-604-1 | | Product Categories: | | | Mol File: | 2253744-53-3.mol |  |
| | DJ-V159 Chemical Properties |
| storage temp. | RT | | solubility | Soluble in DMSO (up to 60 mg/ml). | | form | solid | | color | Off-white | | Stability: | Stable for 2 years from date of purchase? as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| | DJ-V159 Usage And Synthesis |
| Description | GPRC6A? is the receptor for osteocalcin as well as structurally unrelated ligands including L-amino acids, cations and anabolic steroids.1?GPRC6A is a potential therapeutic target for treating type 2 diabetes.2 DJ-V 159 (2253744-53-3) is an agonist at GPRC6A which activates ERK and upregulates cAMP levels in HEK-193 cells expressing GPRC6A. It stimulates insulin secretion in mouse β-cells and lowers blood glucose in mouse models.3 | | storage | Store at RT | | References | 1) Pi and Quarles (2012),?Multiligand specificity and wide tissue expression of GPRC6A reveals new endocrine networks; Endocrinology,?153?2062
2) Pi?et al.?(2016),?GPRC6A: Jack of all metabolism (or master of none); Mol. Metab.,?6?185
3) Pi?et al.?(2018),?Computationally identified novel agonists for GPRC6A; PLoS One,?13?e0195980 |
| | DJ-V159 Preparation Products And Raw materials |
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