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821-50328103-801 18930552037 |
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Product Name:ACEA
CAS:273734-07-9
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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Sigma-Aldrich
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021-61415566 800-8193336 |
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Product Name:Arachidonyl-2′-chloroethylamide
CAS:273734-07-9
Purity:>= 97 % HPLC, oil Package:25mg, 100mg Remarks:A9719
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Neobioscience Co., Ltd.
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4006-800-892 |
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Product Name:Arachidonyl-2-chloroethylamide
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United States Biological
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800.520.3011 or 781.639.5092 |
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chemicals@usbio.net |
| Products Intro: |
Product Name:Arachidonyl-2-chloroethylamide
CAS:273734-07-9
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| Product Name: | ACEA | | Synonyms: | ARACHIDONYL-2'-CHLOROETHYLAMIDE;ARACHIDONYL-2-CHLOROETHYLAMIDE;ARACHIDONOYL 2'-CHLOROETHYLAMIDE;N-(2-CHLOROETHYL)-5Z,8Z,11Z,14Z-EICOSATETRAENAMIDE;ACEA;2'-CHLORO-AEA;Propanamide, 3-chloro-N-(4Z,7Z,10Z,13Z)-4,7,10,13-nonadecatetraen-1-yl- | | CAS: | 273734-07-9 | | MF: | C22H36ClNO | | MW: | 365.98 | | EINECS: | | | Product Categories: | | | Mol File: | 273734-07-9.mol |  |
| storage temp. | −20°C | | solubility | DMSO: soluble | | form | oil | | color | pale yellow |
| Definition | ChEBI: Arachidonyl-2'-chloroethylamide is a fatty amide obtained by the formal condensation of arachidonic acid with 2-chloroethanamine. It is a potent agonist of the CB1 receptor (Ki = 1.4 nM) and also has a low affinity for the CB2 receptor (Ki = 3100 nM). It has a role as a CB1 receptor agonist, a neuroprotective agent and a CB2 receptor agonist. It is an organochlorine compound, a secondary carboxamide, a fatty amide and a synthetic cannabinoid. It is functionally related to an arachidonic acid. | | Enzyme inhibitor | This synthetic CB1 receptor agonist and anandamide (N-
arachidonylethanolamide) analogue (FW = 365.99 g/mol; CAS 220556-69-
4; Symbol: ACEA) is a selective agonist of cannabinoid receptor-1 (Ki =
1.4 nM) but has low affinity to the cannabinoid receptor 2 (Ki = 3.1 μM).
ACEA inhibits forskolin-induced cAMP accumulation in Chinese hamster
ovary cells expressing the human CB1 receptor. It also increases the
binding of [35S]GTPgS to cerebellar membranes and inhibits electrically
evoked contractions of the mouse vas deferens. ACEA produces
hypothermia in mice, an effect that is inhibited by co-administration of the
CB1 receptor antagonist SR141716A. |
| | ACEA Preparation Products And Raw materials |
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