| Company Name: |
United States Biological
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| Tel: |
1-800-520-3011 |
| Email: |
sales@advtechind.com |
| Products Intro: |
Product Name:CYP2A6
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| Product Name: | CYP2A6 | | Synonyms: | CYP2A6 | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![CYP2A6 Structure]() |
| | CYP2A6 Chemical Properties |
| | CYP2A6 Usage And Synthesis |
| Description | The CYP2A6 is the only member of this subfamily that is expressed primarily in the liver and also may be expressed in lung and nasal
epithelium. It has a low level of hepatic expression and represents approximately 4% of the total hepatic CYP450 isoforms. It
catalyzes the 7-hydroxylation of coumarin (coumarin 7-hydroxylase), hydroxylation of aflatoxin B1, nicotine (C-oxidation to cotinine), naproxen, tacrine, clozapine, mexiletine, and cyclobenzaprine as well as the bioactivation of nitrosamines and procarcinogens. The
CYP2A6 exhibits polymorphism with an incidence of 2% in the Caucasian population. This population is characterized as poor
metabolizers. Smokers with a defective CYP2A6 gene smoke fewer cigarettes, implicating a genetic factor in nicotine dependence. |
| | CYP2A6 Preparation Products And Raw materials |
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