PF429242 DIHYDROCHLORIDE
| 中文名称 | PF429242 DIHYDROCHLORIDE |
|---|---|
| 中文同义词 | (R)-4-((二乙氨基)甲基)-N-(2-甲氧基苯乙基)-N-(吡咯烷-3-基)苯甲酰胺二盐酸盐;PF 429242盐酸盐;化合物PF429242 DIHYDROCHLORIDE;PF-429242 二盐酸盐 |
| 英文名称 | PF429242 dihydrochloride |
| 英文同义词 | PF 429242-HCl;PF429242,PF-429242 dihydrochloride,PF429242 dihydrochloride,Virus Protease,inhibit,PF 429242,Inhibitor,Fatty Acid Synthase (FASN),PF-429242 |
| CAS号 | 2248666-66-0 |
| 分子式 | C25H36ClN3O2 |
| 分子量 | 446.03 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 2248666-66-0.mol |
| 结构式 |  |
PF429242 DIHYDROCHLORIDE 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | DMF：30mg/mL； DMSO：30mg/mL；乙醇：30mg/mL； PBS（pH 7.2）：10 mg/mL |
| 形态 | 结晶固体 |
| 颜色 | 白色至浅棕色 |
IC50: 175 nM (S1P)
10 μM PF-429242 inhibits endogenous SREBP processing in Chinese hamster ovary cells. PF-429242 also down-regulates the signal from an SRE-luciferase reporter gene in human embryonic kidney 293 cells and the expression of endogenous SREBP target genes in cultured HepG2 cells. In HepG2 cells, PF-429242 inhibits cholesterol synthesis, with an IC 50 of 0.5 μM. The addition of PF-429242 (30 μM) shows statistically significant suppression of infectious viral titers and viral RNA copies in the cell culture fluids. PF-429242 treatment also shows suppressive effects on DENV2 yields in the cultured fluids of human-derived HEK-293, Hep G2, and non-human-primate derived LLC-MK2 cells. PF-429242 efficiently prevents the processing of GPC from the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) and LASV, which correlates with the compound's potent antiviral activity against LCMV and LASV in cultured cells.
In mice treated with PF-429242 for 24 h, the expression of hepatic SREBP target genes is suppressed, and the hepatic rates of cholesterol and fatty acid synthesis are reduced.