Soluble Epoxide Hydrolase Inhibitor, NCND - CAS 402939-18-8 - Calbiochem
生物活性靶点体内研究 用途与合成方法 MSDS Soluble Epoxide Hydrolase Inhibitor, NCND - CAS 402939-18-8 - Calbiochem价格(试剂级) 上下游产品信息
| 中文名称 | Soluble Epoxide Hydrolase Inhibitor, NCND - CAS 402939-18-8 - Calbiochem |
|---|---|
| 中文同义词 | 化合物1-CYCLOHEXYL-3-DODECYL UREA;1-环己基-3-十二烷基脲;1-环己基-3'-十二烷基脲 |
| 英文名称 | Soluble Epoxide Hydrolase Inhibitor, NCND - CAS 402939-18-8 - Calbiochem |
| 英文同义词 | Soluble Epoxide Hydrolase Inhibitor, NCND - CAS 402939-18-8 - Calbiochem;N-Cyclohexyl-N?-dodecylurea, 1-Cyclohexyl-3?-dodecylurea, CDU;pressure,1 Cyclohexyl 3 dodecyl urea,epoxyeicosatrienoic,inhibit,Inhibitor,acid,1Cyclohexyl3dodecyl urea,antihypertensive,Epoxide Hydrolase,EET,blood;Urea, N-cyclohexyl-N'-dodecyl- |
| CAS号 | 402939-18-8 |
| 分子式 | C19H38N2O |
| 分子量 | 310.52 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 402939-18-8.mol |
| 结构式 |  |
Soluble Epoxide Hydrolase Inhibitor, NCND - CAS 402939-18-8 - Calbiochem 性质
| 沸点 | 465.1±12.0 °C(Predicted) |
|---|---|
| 密度 | 0.92±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 乙醇：16.67 mg/mL（53.68 mM） |
| 酸度系数(pKa) | 14.29±0.20(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
1-Cyclohexyl-3-dodecyl urea (CDU, N-Cyclohexyl-N-dodecyl urea, NCND) 是一种高选择性的 soluble epoxide hydrolase (sEH) 的抑制剂，可增加 epoxyeicosatrienoic acids (EETs) 的表达水平。
| Target | Value |
|
sEH
() |
1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) ( intraperitoneal injection; 3mg/day; 4 days) lowers systolic blood pressure by 30 mm Hg in Ang II hypertensive animals, whereas the corn oil vehicle has no effect on blood pressure in normotensive or Ang II hypertensive animals.
| Animal Model: | Male Sprague-Dawley rats |
| Dosage: | 3mg/day |
| Administration: | Intraperitoneal injection; 4 days |
| Result: | Had antihypertensive properties. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | S0548 | Soluble Epoxide Hydrolase Inhibitor, NCND - CAS 402939-18-8 - Calbiochem 1-Cyclohexyl-3-dodecyl urea | 402939-18-8 | 5mg | 670.48元 |
| 2024/04/30 | S0548 | Soluble Epoxide Hydrolase Inhibitor, NCND - CAS 402939-18-8 - Calbiochem 1-Cyclohexyl-3-dodecyl urea | 402939-18-8 | 25mg | 3380.33元 |