| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:YW1128
CAS:2131223-64-6
Purity:98% Package:1G;10G;100G Remarks:YW1128 is an inhibitor of Wnt/β-catenin signaling. It decreases protein levels of β-catenin in the presence of the GSK3β inhibitor lithium chloride and increases protein levels of Axin1 in HEK293 cell
|
| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Email: |
sales@dcchemicals.com |
| Products Intro: |
Product Name:YW1128
CAS:2131223-64-6
Purity:98% HPLC Package:100mg，250mg，1g
|
| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:YW1128
CAS:2131223-64-6
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
YW1128 manufacturers
- YW1128
-
- $1340.00 / 10mg
-
2024-10-28
- CAS:2131223-64-6
- Min. Order:
- Purity:
- Supply Ability: 10g
|
| Product Name: | YW1128 | | Synonyms: | 3-triazole-4-carboxamide;5-methyl-1-(2-methylphenyl)-N-2-quinolinyl-1H-1;5-METHYL-1-(2-METHYLPHENYL)-N-2-QUINOLINYL-1H-1;2;3-TRIAZOLE-4-CARBOXAMIDE;YW1128;1H-1,2,3-Triazole-4-carboxamide, 5-methyl-1-(2-methylphenyl)-N-2-quinolinyl-;YW1128,YW-1128 | | CAS: | 2131223-64-6 | | MF: | C20H17N5O | | MW: | 343.38 | | EINECS: | | | Product Categories: | | | Mol File: | 2131223-64-6.mol |  |
| | YW1128 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 30mg/mL; DMSO: 30mg/mL; Ethanol: 30mg/mL; PBS (pH 7.2): 2mg/mL | | form | A crystalline solid | | color | White to off-white |
| | YW1128 Usage And Synthesis |
| Description | YW1128 is an inhibitor of Wnt/β-catenin signaling with an IC50 value of 4.1 nM in a reporter assay. It decreases protein levels of β-catenin in the presence of the GSK3β inhibitor lithium chloride and increases protein levels of Axin1 in HEK293 cells. YW1128 decreases lipid accumulation and the expression of gluconeogenic and lipogenic genes in Huh7 cells. It decreases the hepatic expression of Wnt target genes, improves glucose tolerance, and prevents body weight increases and hepatic lipid accumulation in mice fed a high-fat diet, but not mice fed normal chow, when administered at a dose of 40 mg/kg every other day for 11 weeks. |
| | YW1128 Preparation Products And Raw materials |
|