Company Name: |
Sichuan Wei Keqi Biological Technology Co., Ltd.
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Tel: |
028-81700200 18116577057 |
Email: |
3003855609@qq.com |
Products Intro: |
Product Name:PF-00356231hydrochloride CAS:820223-77-6 Purity:98% Package:5mg;10mg;20mg;50mg;100mg;200mg;500mg;1g
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Company Name: |
Beijing Jin Ming Biotechnology Co., Ltd.
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Tel: |
010-60605840 15801484223; |
Email: |
psaitong@jm-bio.com |
Products Intro: |
Product Name:PF-00356231 hydrochloride CAS:820223-77-6 Purity:98% Package:1mg
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| PF-00356231 hydrochloride Basic information |
| PF-00356231 hydrochloride Chemical Properties |
storage temp. | Store at -20°C | solubility | Soluble in DMSO | form | Solid | color | White to light yellow |
| PF-00356231 hydrochloride Usage And Synthesis |
Biological Activity | PF-00356231 hydrochloride is a non-peptide, non-zinc-chelating matrix metalloprotease MMP-12 ligand and inhibitor (IC50=1.4 μM). It is specific for MMP-12 and forms the PF-00356231/MMP-12 complex. | in vitro | PF-00356231 hydrochloride against MMP-12/13 can be affected significantly by the presence of acetohydroxamate (AH). It decreases the IC 50 values of MMP-12 ( 0.014 μM) and MMP-13 (0.27 μM) in the presence AH. | target | MMP-12 < span> 1.4 μM (IC 50 ) | MMP13 0.65 nM (IC 50 ) | MMP-3 < span> 0.39 μM (IC 50 ) | MMP-8 1.7 μM (IC 50 ) | MMP-9 0.98 μM (IC 50 ) | |
| PF-00356231 hydrochloride Preparation Products And Raw materials |
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