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| | MAC-545496 Basic information |
| Product Name: | MAC-545496 | | Synonyms: | MAC-545496;Benzamide, N-[[(5-chloro-2-pyridinyl)amino]thioxomethyl]-3-nitro-4-(1-piperidinyl)-;N-[[(5-Chloro-2-pyridinyl)amino]thioxomethyl]-3-nitro-4-(1-piperidinyl)benzamide;Bacterial,S. aureus,Antivirulence,Inhibitor,MAC545496,mprF,nanomolar,GraR,MAC-545496,MRSA,survival,inhibit,biofilm,MAC 545496,virulence,β-lactam;N-((5-Chloropyridin-2-yl)carbamothioyl)-3-nitro-4-(piperidin-1-yl)benzamide | | CAS: | 838810-96-1 | | MF: | C18H18ClN5O3S | | MW: | 419.89 | | EINECS: | | | Product Categories: | | | Mol File: | 838810-96-1.mol |  |
| | MAC-545496 Chemical Properties |
| density | 1.458±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | Soluble in DMSO (25 mg/ml) | | form | solid | | pka | 7.09±0.70(Predicted) | | color | Yellow/orange | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month |
| | MAC-545496 Usage And Synthesis |
| Description | MAC-545496 (838810-96-1) is an inhibitor of glycopeptide-resistance-associated protein R (GraR, also known as ApsR).? GraR and its regulatory system are important for virulence of S. aureus.? MAC-545496 is able to reverse ?-lactam resistance in S. aureus in a G. Mellonella larvae model.? 0.06 μg/mL MAC-545496? lowered the minimum inhibitory concentration (MIC) for oxacillin against S. aureus below the CLSI clinical breakpoint. It lowered the ?-lactam MIC from 512 to 8 μg/mL against S. aureus USA300. | | References | El-Halfawy et al. (2020), Discovery of an antivirulence compound that reverses ?-lactam resistance in MRSA; Nat. Chem. Biol., 16 143 |
| | MAC-545496 Preparation Products And Raw materials |
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