| Company Name: |
Shanghai Chaolan Chemical Technology Center
|
| Tel: |
QQ:65489617 15618227136 |
| Email: |
info@SuperLan-chem.com |
| Products Intro: |
Product Name:GPX4-Activator-1d4
CAS:2143896-83-5
Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G,100G
|
| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
|
| Tel: |
400-9205774 |
| Email: |
sales@glpbio.cn |
| Products Intro: |
Product Name:PKUMDL-LC-101-D04
CAS:2143896-83-5
Purity:>98% Package:1mg;10mg;50mg;100mg;
|
|
| | PKUMDL-LC-101-D04 Basic information |
| Product Name: | PKUMDL-LC-101-D04 | | Synonyms: | GPX4-Activator-1d4;PKUMDL-LC-101-D04;PKUMDL LC 101 D04,PKUMDL-LC-101-D-04,PKUMDLLC101D04;N-(2-aminoethyl)-4-[[(cyclopentylamino)thioxomethyl]amino]-benzenesulfonamide, monohydrochloride | | CAS: | 2143896-83-5 | | MF: | C14H23ClN4O2S2 | | MW: | 378.93 | | EINECS: | | | Product Categories: | | | Mol File: | 2143896-83-5.mol |  |
| | PKUMDL-LC-101-D04 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO: soluble | | form | A crystalline solid | | color | White to off-white |
| | PKUMDL-LC-101-D04 Usage And Synthesis |
| Description | PKUMDL-LC-101-D04 is an allosteric activator of glutathione peroxidase 4 (GPX4).1 It increases GPX4 activity to 150% of control levels when used at a concentration of 20 μM in a cell-free assay and at 61 μM in wild-type, but not Gpx4-/-, mouse embryonic fibroblast (MEF) extracts. PKUMDL-LC-101-D04 (200 μM) also reduces cholesterol hydroperoxide-induced MEF death. | | References | 1. Li, C., Deng, X., Zhang, W., et al. Novel allosteric activators for ferroptosis regulator glutathione peroxidase 4 J. Med. Chem. 62(1),266-275(2019). |
| | PKUMDL-LC-101-D04 Preparation Products And Raw materials |
|