Company Name: |
Nanjing Chemlin Chemical Co., Ltd
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Tel: |
025-83697070 |
Email: |
info@chemlin.com.cn |
Products Intro: |
Product Name:4-(trifluoromethoxy)-N-(2-(trifluoromethyl)benzyl)benzimidamide CAS:305339-41-7 Purity:98% Package:1mg;5mg;50mg;500mg;5g;50g
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Product Name: | BZAD01 | Synonyms: | BZAD01;Inhibitor,NR2B,NMDA,iGluR,BZAD01,Ionotropic glutamate receptors,inhibit;Benzenecarboximidamide, 4-(trifluoromethoxy)-N-[[2-(trifluoromethyl)phenyl]methyl]-;4-(trifluoromethoxy)-N-(2-(trifluoromethyl)benzyl)benzimidamide | CAS: | 305339-41-7 | MF: | C16H12F6N2O | MW: | 362.27 | EINECS: | | Product Categories: | | Mol File: | 305339-41-7.mol | ![BZAD01 Structure](CAS/20210111/GIF/305339-41-7.gif) |
| BZAD01 Chemical Properties |
Boiling point | 340.8±52.0 °C(Predicted) | density | 1.34±0.1 g/cm3(Predicted) | storage temp. | 4°C, protect from light | solubility | Methanol : 250 mg/mL (690.09 mM; Need ultrasonic)|DMSO : 100 mg/mL (276.04 mM; Need ultrasonic) | pka | 9.56±0.50(Predicted) | form | Solid | color | White to off-white |
| BZAD01 Usage And Synthesis |
Biological Activity | BZAD-01 is a potent, selective and orally active inhibitor of NMDA NR2B subunit, with a Ki of 72 nM. BZAD-01 can improve postural asymmetry as well as Apomorphine-induced rotation[1]. | References | [1]. Truong L, et, al. Behavioural effects of a selective NMDA NR1A/2B receptor antagonist in rats with unilateral 6-OHDA+parafascicular lesions. Brain Res Bull. 2009 Feb 16;78(2-3):91-6. |
| BZAD01 Preparation Products And Raw materials |
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