Company Name: |
J & K SCIENTIFIC LTD.
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Tel: |
010-82848833 400-666-7788 |
Email: |
jkinfo@jkchemical.com |
Products Intro: |
Product Name:Topotecan-d6 CAS:1044904-10-0 Package:10Mg,1Mg
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Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
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Tel: |
400-9205774 |
Email: |
sales@glpbio.cn |
Products Intro: |
Product Name:Topotecan-d6 CAS:1044904-10-0 Purity:>98% Package:1mg;10mg;50mg;100mg;
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| TOPOTECAN-D6 Basic information |
Product Name: | TOPOTECAN-D6 | Synonyms: | TOPOTECAN-D6;(4S)-10-[[Di(methyl-d3)amino]methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[346-7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;SKF-104864A-d6;(4S)-10-[(Dimethylamino-d6)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3’,4’,6-7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;Hycamtin-d6;NSC-609669-d6;(4S)-10-[[Di(methyl-d3)amino]methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;[2H6]-Topotecan | CAS: | 1044904-10-0 | MF: | C23H23N3O5 | MW: | 421.45 | EINECS: | | Product Categories: | Heterocycles;Isotope Labelled Compounds;Inhibitors;Intermediates & Fine Chemicals;Isotope Labeled Compounds;Pharmaceuticals | Mol File: | 1044904-10-0.mol | ![TOPOTECAN-D6 Structure](CAS/GIF/1044904-10-0.gif) |
| TOPOTECAN-D6 Chemical Properties |
Melting point | 213-218°C (dec) | storage temp. | -20°C Freezer | solubility | aqueous acid: soluble; DMSO: slightly; Methanol: soluble | form | A solid | color | Light yellow to yellow | Stability: | Hygroscopic | CAS DataBase Reference | 1044904-10-0 |
| TOPOTECAN-D6 Usage And Synthesis |
Description | Topotecan-d6 is intended for use as an internal standard for the quantification of topotecan by GC- or LC-MS. Topotecan is an inhibitor of DNA topoisomerase I and a derivative of the DNA topoisomerase I inhibitor camptothecin . Topotecan inhibits DNA topoisomerase I in human MCF-7 breast and DU145 prostate cancer cells with IC50 values of 13 and 2 nM, respectively, in a cell-based luciferase reporter assay. Topotecan induces cytotoxicity and DNA damage in HT-29 human colon adenocarcinoma cells (IC50s = 33 and 280 nM, respectively). Formulations containing topotecan have been used in the treatment of small-cell lung cancer. | Chemical Properties | Light Yellow to Greenish Powder | Uses | Labelled Topotecan (T542500). A DNA topoisomerase I inhibitor; semisynthetic analog of Camptothecin. Antineoplastic. | Uses | Labelled Topotecan. A DNA topoisomerase I inhibitor; semisynthetic analog of Camptothecin. Antineoplastic |
| TOPOTECAN-D6 Preparation Products And Raw materials |
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