SUCCINYL-ASP-PHE-ME-PHE-GLY-LEU-MET-NH2
| 中文名称 | SUCCINYL-ASP-PHE-ME-PHE-GLY-LEU-MET-NH2 |
|---|---|
| 中文同义词 | 琥珀酰基-天冬氨酰-苯丙氨酰-(N-甲基)-苯丙氨酰-甘氨酰-亮氨酰-蛋氨酸胺;速激肽NK-3受体激动剂多肽;P物质肽[SUC-ASP6, ME-PHE8] SUBSTANCE P;SENKTIDE,速激肽NK3激动剂 |
| 英文名称 | SENKTIDE |
| 英文同义词 | succinyl(asp6;Substance P, fragment 6-11, succinyl[Asp6, NMePhe8];M.W. 842.1 C40H55N7O11S;N-(3-Carboxy-1-oxopropyl)-L-Asp-L-Phe-N-methyl-L-Phe-Gly-L-Leu-L-Met-NH2;N-(3-Carboxy-1-oxopropyl)-L-αAsp-L-Phe-N-methyl-L-Phe-Gly-L-Leu-L-Met-NH2;Suc-[Asp6,MePhe8]substance P(6-11);[SUCCINYL-ASP6,ME-PHE8] SUBSTANCE P;SUCCINYL-(ASP6,N-ME-PHE8)-SUBSTANCE P (6-11) |
| CAS号 | 106128-89-6 |
| 分子式 | C40H55N7O11S |
| 分子量 | 841.97 |
| EINECS号 | |
| 相关类别 | 多肽;标准品;peptide;Tachykinin receptor |
| Mol文件 | 106128-89-6.mol |
| 结构式 |  |
SUCCINYL-ASP-PHE-ME-PHE-GLY-LEU-MET-NH2 性质
| 沸点 | 1262.6±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.290±0.06 g/cm3(Predicted) |
| 储存条件 | −20°C |
| 溶解度 | DMSO：50 mg/mL（59.38 mM；需要超声波） |
| 酸度系数(pKa) | 4.23±0.10(Predicted) |
| 形态 | 膜状 |
| 颜色 | 无色 |
NK 3 receptor
The selective NK 3 receptor agonist Senktide excites 24 of 31 dopaminergic neurons in the substantia nigra pars compacta in a concentration-dependent manner. The effective concentration range is between 3 to 3000 nm. The mean EC 50 for Senktide is 41.2±9 nm (n=5).
I.c.v. injection of Senktide causes a dose-dependent increase in total distance traveled (F 6,72 =6.344, P<0.001). This increase reaches statistical significance compare to the vehicle-treated group at 0.06 nmol and higher. The Senktide-induced increase in locomotor activity brought about by 0.1 nmol of Senktide is significantly and dose-dependently decreased by the tachykinin NK 3 receptor antagonists talnetant at 30 mg/kg and SB222200 at 30 mg/kg, but not by osanetant, when tested in parallel in a single experiment (F 7,78 =10.32, P<0.001), although a non-significant reduction is observed. However, when tested using another vehicle (Vitamin E and glycofurol), osanetant does decrease activity significantly compare to Senktide-treated gerbils (F 2,30 =10.10, P<0.001).
安全信息
| WGK Germany | 3 |
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| 提供商 | 语言 |
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-P0187 | SUCCINYL-ASP-PHE-ME-PHE-GLY-LEU-MET-NH2 Senktide | 106128-89-6 | 1mg | 700元 |
| 2024/04/30 | HY-P0187 | SUCCINYL-ASP-PHE-ME-PHE-GLY-LEU-MET-NH2 Senktide | 106128-89-6 | 5mg | 1600元 |