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MONOCLONAL ANTI-HNRNP-C1/C2

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MONOCLONAL ANTI-HNRNP-C1/C2 Suppliers list
Company Name: Riedel-de Haen AG  
Tel: 800 558-9160
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Products Intro: Remarks:clone 4F4, purified immunoglobulin, buffered aqueous solution
Company Name: SIGMA-RBI  
Tel: 800 736 3690 (Orders)
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MONOCLONAL ANTI-HNRNP-C1/C2 Basic information
Product Name:MONOCLONAL ANTI-HNRNP-C1/C2
Synonyms:Anti-Heterogeneous Nuclear Ribonucleoprotein-C1/C2;Monoclonal Anti-hnRNP-C1/C2 antibody produced in mouse;MONOCLONAL ANTI-HNRNP-C1/C2
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MW:0
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Mol File:Mol File
MONOCLONAL ANTI-HNRNP-C1/C2 Structure
MONOCLONAL ANTI-HNRNP-C1/C2 Chemical Properties
storage temp. −20°C
form buffered aqueous solution
Safety Information
WGK Germany -
MSDS Information
ProviderLanguage
SigmaAldrich English
MONOCLONAL ANTI-HNRNP-C1/C2 Usage And Synthesis
UsesMonoclonal Anti-hnRNP-C1/C2 antibody produced in mouse has been used in:
  • antibody microarray
  • western blotting
  • enzyme linked immunosorbent assay (ELISA)`
  • immunoprecipitation
  • immunocytochemistry

General DescriptionMonoclonal Anti-hnRNP-C1/C2 (mouse IgG1isotype) is derived from the 4F4 hybridoma produced by the fusion of mouse myeloma cells (SP2/0 cells) and splenocytes from BALB/c mice immunized with RNPs eluted from oligo (dT) cellulose column. Heterogeneous nuclear ribonucleoproteins C1/C2 (HnRNP C1/C2) are synthesized from C2 protein by alternative splicing and have an additional13-amino-acids. It is localized in nucleus and has leucine zipper-like RNA-binding motif. The hnRNP-C proteins have a single ribonucleoprotein (RNP) motif RNA-binding domain (RBD) of 80 to 100 amino acid long.
Biochem/physiol ActionsHeterogeneous nuclear ribonucleoproteins C1/C2(HnRNP C1/C2) is involved in protein translation, mRNA biogenesis and transport. The hnRNP-C proteins preferentially bind to uridine-rich RNA sequences. Oligomerization of the protein through leucine rich regions in its C-terminal end is important for RNA binding. Mutation of the hnRNPC gene is implicated in embryonic lethal phenotype.
MONOCLONAL ANTI-HNRNP-C1/C2 Preparation Products And Raw materials
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