Company Name: |
Sigma-Aldrich
|
Tel: |
021-61415566 800-8193336 |
Email: |
orderCN@merckgroup.com |
Products Intro: |
Product Name:Anti-Cholera Toxin Purity:whole antiserum Package:1mL Remarks:C3062
|
Company Name: |
Riedel-de Haen AG
|
Tel: |
800 558-9160 |
Email: |
|
Products Intro: |
Purity:whole antiserum
|
Company Name: |
SIGMA-RBI
|
Tel: |
800 736 3690 (Orders) |
Email: |
|
Products Intro: |
|
Company Name: |
OEM Concepts
|
Tel: |
877 341 3570 (Toll free) |
Email: |
|
Products Intro: |
|
|
| ANTI-CHOLERA TOXIN Basic information |
| ANTI-CHOLERA TOXIN Chemical Properties |
Hazard Codes | Xn | Risk Statements | 21/22 | Safety Statements | 36/37 | WGK Germany | 3 |
| ANTI-CHOLERA TOXIN Usage And Synthesis |
Uses | Anti-Cholera Toxin antibody produced in rabbit has been used in:
- western blotting
- quantitative ganglioside-dependent enzyme-linked immunoassay (ELISA)
- double immunodiffusion
| General Description | Cholera toxin, the pathogenic agent of cholera, is made of two subunits, A (27 kDa) and B (12 kDa) assembled with the stoichiometry AB5. The B-subunit binds to specific receptors, the monosialogangliosides GM1, located in the membrane of intestinal epithelial cells. The A1 fragment of the A-subunit is translocated through the membrane of the host cell, where it catalyses the ADP-ribosylation of the Gsa regulatory component of the adenylate cyclase complex. The resulting increased level of cyclic AMP promotes a wide variety of actions, including the secretion of chloride ions in the case of intestinal epithelial cells. | Biochem/physiol Actions | Cholera toxin (CT), a multifunctional protein plays a role in the immune system. It possesses immunomodulatory, adjuvant properties and also acts as an anti-inflammatory agent. Its immunomodulatory properties can be utilized to treat several autoimmune disorders. CT can serve as one of the best model of a multifunctional protein. |
| ANTI-CHOLERA TOXIN Preparation Products And Raw materials |
|