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ANTI-GUANYLATE CYCLASE A1

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ANTI-GUANYLATE CYCLASE A1 Suppliers list
Company Name: Riedel-de Haen AG  
Tel: 800 558-9160
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Products Intro: Remarks:IgG fraction of antiserum, buffered aqueous solution
Company Name: SIGMA-RBI  
Tel: 800 736 3690 (Orders)
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ANTI-GUANYLATE CYCLASE A1 Basic information
Product Name:ANTI-GUANYLATE CYCLASE A1
Synonyms:ANTI-GUANYLATE CYCLASE A1;Anti-Guanylyl Cyclase α1 antibody produced in rabbit
CAS:
MF:
MW:0
EINECS:
Product Categories:Alphabetical Index;Antibodies for Cell Stress;Antibodies for Nitric Oxide ResearchAntibodies;Cell Biology;G
Mol File:Mol File
ANTI-GUANYLATE CYCLASE A1 Structure
ANTI-GUANYLATE CYCLASE A1 Chemical Properties
storage temp. -20°C
form buffered aqueous solution
Safety Information
WGK Germany 2
MSDS Information
ProviderLanguage
SigmaAldrich English
ANTI-GUANYLATE CYCLASE A1 Usage And Synthesis
UsesAnti-Guanylyl Cyclase α1 antibody produced in rabbit is suitable for immunohistochemistry at a working dilution of 1:100 using trypsin-treated human, bovine and mouse heart tissue and immunoprecipitation at 5-10μg concentration using 60-120μg of a cytosolic fraction of rat brain. It is also suitable for western blot analysis using cytosolic fraction of rat brain at a working dilution of 1:10,000.
It was used as a primary antibody for immunohistochemical:
  • localization of α1 subunits of sGC (soluble guanylate cyclase) in the guinea pig gastrointestinal tract
  • detection of expression of sGC in the vasculature of rat skeletal muscle
  • localization of the functional subunit of NO receptors, sGCα1 in guinea pig caecum
General DescriptionThe enzyme consists of α and β subunits of ~80kDa and ~70kDa respectively. Both the units are required for catalytic activity. The N-terminal domains of the subunits are essential for the stimulation of the enzyme by NO. Dimerization is mediated by the central portion of GC. The C-terminus domain of both subunits forms the catalytic domain.
Biochem/physiol ActionsGuanylyl cyclase (GC) catalyzes the conversion of guanosine-5′-triphosphate (GTP) to cyclic guanosine-3′,5-monophosphate (cGMP) and pyrophosphate. This reaction requires Mg2+ or Mn2+.
ANTI-GUANYLATE CYCLASE A1 Preparation Products And Raw materials
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