| Company Name: |
Shenzhen Botel Biotechnology Co. Ltd.
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0755-22202135 13316968096 |
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1979313431@qq.com |
| Products Intro: |
Product Name:Alvimopan metabolite (ADL08-0011),hydrochloride salt
Purity:98% HPLC Package:10mg;25mg;50mg
|
| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:ADL 08-0011 (hydrochloride)
CAS:170098-43-8
Purity:90% Package:1mg;5mg;10mg
|
| Company Name: |
guoyungurui
|
| Tel: |
18162595016 |
| Email: |
3287908757@qq.com |
| Products Intro: |
Product Name:Alvimopan metabolite (ADL08-0011),hydrochloride salt
CAS:170098-43-8
Purity:95%+HPLC Package:10mg;25mg;50mg;100mg;200mg
|
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| | Alvimopan metabolite (ADL08-0011),hydrochloride salt Basic information |
| | Alvimopan metabolite (ADL08-0011),hydrochloride salt Chemical Properties |
| storage temp. | -20°C | | solubility | DMSO: soluble,Methanol: soluble | | form | A solid |
| | Alvimopan metabolite (ADL08-0011),hydrochloride salt Usage And Synthesis |
| Biological Activity | ADL 08-0011 is an active metabolite of the μ-opioid receptor antagonist alvimopan .1 It is produced from alvimopan via amide hydrolysis by gut microbiota. ADL 08-0011 is a μ-opioid receptor antagonist (Ki = 0.25 nM). It is selective for μ-opioid receptors over κ- and δ-opioid receptors (Kis = 15.8 and 31.6 nM, respectively). ADL 08-0011 inhibits endomorphin 1-induced inhibition of electrically induced contraction of isolated guinea pig ileum (pA2 = 9.4). In vivo, ADL 08-0011 (0.03-1 mg/kg) reverses loperamide-induced delayed gastric emptying in a rat model of castor oil-induced diarrhea.2 | | References | 1.Beattie, D.T., Cheruvu, M., Mai, N., et al.The in vitro pharmacology of the peripherally restricted opioid receptor antagonists, alvimopan, ADL 08-0011 and methylnaltrexoneNaunyn Schmiedebergs Arch. Pharmacol.375(3)205-220(2007)
2.Armstrong, S.R., Campbell, C.B., Richardson, C.L., et al.The in vivo pharmacodynamics of the novel opioid receptor antagonist, TD-1211, in models of opioid-induced gastrointestinal and CNS activityNaunyn Schmiedebergs Arch Pharmacol.386(6)471-478(2013) |
| | Alvimopan metabolite (ADL08-0011),hydrochloride salt Preparation Products And Raw materials |
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